BIOINFORMATIC ANALYSIS OF THE FUNCTIONAL AND STRUCTURAL IMPLICATIONS OF ALTERNATIVE SPLICING.

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dc.contributor.advisorMoult, Johnen_US
dc.contributor.authorMelamud, Eugeneen_US
dc.contributor.departmentMolecular and Cell Biologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2007-06-22T05:31:20Z
dc.date.available2007-06-22T05:31:20Z
dc.date.issued2007-01-23
dc.description.abstractIn higher Eukaryotes, upon transcription of a gene, a complex set of reactions take place to remove fragments of a sequence (introns) from transcribed RNA. A large macro-molecular machine (the spliceosome) recognizes the ends of introns, brings ends into close proximity and catalyzes the splicing reaction. The selection of the location of the ends of introns (splice sites) determines the final message produced at the end of the process. In some cases, an alternative set of splice sites are chosen, and as a consequence different message is produced. This phenomenon is known as alternative splicing. It is now realized that nearly every Human gene undergoes alternative splicing, producing large variability in types and number of transcripts produced. In this thesis, we examine the functional and structural consequences of alternative splicing on proteins, we look into the mechanism of formation of complex splicing patterns, and examine the role of noise in the process.en_US
dc.format.extent15518659 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/6683
dc.language.isoen_US
dc.subject.pqcontrolledBiology, Bioinformaticsen_US
dc.subject.pqcontrolledBiology, Biostatisticsen_US
dc.subject.pqcontrolledBiology, Bioinformaticsen_US
dc.subject.pquncontrolledAlternative Splicingen_US
dc.subject.pquncontrolledProtein Stabilityen_US
dc.subject.pquncontrolledSystem Robustnessen_US
dc.subject.pquncontrolledSplicing Patternsen_US
dc.subject.pquncontrolledBioinformaticsen_US
dc.subject.pquncontrolledEvolution;en_US
dc.titleBIOINFORMATIC ANALYSIS OF THE FUNCTIONAL AND STRUCTURAL IMPLICATIONS OF ALTERNATIVE SPLICING.en_US
dc.typeDissertationen_US

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