Cardiorespiratory Fitness as a Moderator of Sleep-Related Associations with Hippocampal Volume and Cognition

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dc.contributor.authorAlfini, Alfonso J.
dc.contributor.authorWon, Junyeon
dc.contributor.authorWeiss, Lauren R.
dc.contributor.authorNyhuis, Casandra C.
dc.contributor.authorZipunnikov, Vadim
dc.contributor.authorSpira, Adam P.
dc.contributor.authorLiu-Ambrose, Teresa
dc.contributor.authorShackman, Alexander J.
dc.contributor.authorSmith, J. Carson
dc.date.accessioned2023-10-19T17:26:31Z
dc.date.available2023-10-19T17:26:31Z
dc.date.issued2022-10-07
dc.description.abstractThe objective of this study was to understand the associations of sleep and cardiorespiratory fitness with hippocampal volume and global cognition among older adults (n = 30, age = 65.8 years, female = 73.3%). Wrist actigraphy provided objective measures of nighttime sleep including sleep duration, average wake bout length (WBL; sleep disturbance), and wake-to-sleep transition probability (WTSP; sleep consolidation). Cardiorespiratory fitness was quantified via cycle exercise using a modified heart rate recovery approach. Magnetic resonance imaging was used to determine hippocampal volume and the Mini-Mental State Examination was used to assess global cognition. Fitness moderated associations of sleep with hippocampal volume and cognitive performance, whereby the association of WBL—an index of poor sleep—with hippocampal atrophy was stronger among less-fit individuals, and the association of sleep duration with cognitive performance was stronger among more-fit individuals. Across the fitness levels, a longer WBL was associated with lower cognitive performance, and a higher WTSP—an index of more consolidated sleep—was associated with greater hippocampal volume. Sleep and fitness were unrelated to the volume of an amygdala control region, suggesting a degree of neuroanatomical specificity. In conclusion, higher cardiorespiratory fitness may attenuate sleep disturbance-related hippocampal atrophy and magnify the cognitive benefits of good sleep. Prospective studies are needed to confirm these findings.
dc.description.urihttps://doi.org/10.3390/brainsci12101360
dc.identifierhttps://doi.org/10.13016/dspace/9tua-w8cb
dc.identifier.citationAlfini, A.J.; Won, J.; Weiss, L.R.; Nyhuis, C.C.; Zipunnikov, V.; Spira, A.P.; Liu-Ambrose, T.; Shackman, A.J.; Smith, J.C. Cardiorespiratory Fitness as a Moderator of Sleep-Related Associations with Hippocampal Volume and Cognition. Brain Sci. 2022, 12, 1360.
dc.identifier.urihttp://hdl.handle.net/1903/31063
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtSchool of Public Healthen_us
dc.relation.isAvailableAtKinesiologyen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectsleep
dc.subjectactigraphy
dc.subjectbrain volume
dc.subjectheart rate recovery
dc.subjectaging
dc.titleCardiorespiratory Fitness as a Moderator of Sleep-Related Associations with Hippocampal Volume and Cognition
dc.typeArticle
local.equitableAccessSubmissionNo

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