Hippocampal and Cerebral Blood Flow after Exercise Cessation in Master Athletes

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dc.contributor.authorAlfini, Alfonso J.
dc.contributor.authorWeiss, Lauren R.
dc.contributor.authorLeitner, Brooks P.
dc.contributor.authorSmith, Theresa J.
dc.contributor.authorHagberg, James M.
dc.contributor.authorSmith, J. Carson
dc.date.accessioned2017-08-31T16:40:52Z
dc.date.available2017-08-31T16:40:52Z
dc.date.issued2016-08-05
dc.descriptionPartial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.en_US
dc.description.abstractWhile endurance exercise training improves cerebrovascular health and has neurotrophic effects within the hippocampus, the effects of stopping this exercise on the brain remain unclear. Our aim was to measure the effects of 10 days of detraining on resting cerebral bloodflow (rCBF) in gray matter and the hippocampus in healthy and physically fit older adults. We hypothesized that rCBF would decrease in the hippocampus after a 10-day cessation of exercise training. Twelve master athletes, defined as older adults (age ≥ 50 years) with long-term endurance training histories (≥ 15 years), were recruited from local running clubs. After screening, eligible participants were asked to cease all training and vigorous physical activity for 10 consecutive days. Before and immediately after the exercise cessation period, rCBF was measured with perfusion-weighted MRI. A voxel-wise analysis was used in gray matter, and the hippocampus was selected a priori as a structurally defined region of interest (ROI), to detect rCBF changes overtime. Resting CBF significantly decreased in eight gray matter brain regions. These regions included: (L) inferior temporal gyrus, fusiform gyrus, inferior parietal lobule, (R) cerebellar tonsil, lingual gyrus, precuneus, and bilateral cerebellum (FEW p < 0.05). Additionally, rCBF within the left and right hippocampus significantly decreased after 10 days of no exercise training. These findings suggest that the cerebrovascular system, including the regulation of resting hippocampal blood flow, is responsive to short-term decreases in exercise training among master athletes. Cessation of exercise training among physically fit individuals may provide a novel method to assess the effects of acute exercise and exercise training on brain function in older adults.en_US
dc.identifierhttps://doi.org/10.13016/M2804XK2D
dc.identifier.citationAlfini AJ, Weiss LR, Leitner BP, Smith TJ, Hagberg JM and Smith JC (2016) Hippocampal and Cerebral Blood Flow after Exercise Cessation in Master Athletes. Front. Aging Neurosci. 8:184. doi: 10.3389/fnagi.2016.00184en_US
dc.identifier.urihttp://hdl.handle.net/1903/19696
dc.language.isoen_USen_US
dc.publisherFrontiersen_US
dc.relation.isAvailableAtSchool of Public Healthen_us
dc.relation.isAvailableAtKinesiologyen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectaerobic fitnessen_US
dc.subjectarterial spin labelingen_US
dc.subjectathleteen_US
dc.subjectcerebral blood flowen_US
dc.subjectcerebrovascular healthen_US
dc.subjecthealthy older adultsen_US
dc.subjecthippocampusen_US
dc.subjectMRIen_US
dc.titleHippocampal and Cerebral Blood Flow after Exercise Cessation in Master Athletesen_US
dc.typeArticleen_US

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