Randomized Controlled Trial to Improve Adiposity, Inflammation, and Insulin Resistance in Obese African-American and Latino Youth

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dc.contributor.authorHasson, Rebecca E.
dc.contributor.authorAdam, Tanja C.
dc.contributor.authorDavis, Jaimie N.
dc.contributor.authorKelly, Louise A.
dc.contributor.authorVentura, Emily E.
dc.contributor.authorByrd-Williams, Courtney E.
dc.contributor.authorToledo-Corral, Claudia M.
dc.contributor.authorRoberts, Christian K.
dc.contributor.authorLane, Christianne J.
dc.contributor.authorAzen, Stanley P.
dc.contributor.authorChou, Chih-Ping
dc.contributor.authorSpruijt-Metz, Donna
dc.contributor.authorWeigensberg, Mark J.
dc.contributor.authorBerhane, Kiros
dc.contributor.authorGoran, Michael I.
dc.date.accessioned2019-08-14T15:02:23Z
dc.date.available2019-08-14T15:02:23Z
dc.date.issued2011
dc.description.abstractThe purpose of this study was to examine ethnic differences in the metabolic responses to a 16-week intervention designed to improve insulin sensitivity (SI), adiposity, and inflammation in obese African-American and Latino adolescents. A total of 100 participants (African Americans: n = 48, Latino: n = 52; age: 15.4 ± 1.1 years, BMI percentile: 97.3 ± 3.3) were randomly assigned to interventions: control (C; n = 30), nutrition (N; n = 39, 1×/week focused on decreasing sugar and increasing fiber intake), or nutrition + strength training (N+ST; n = 31, 2×/week). The following were measured at pre- and postintervention: strength, dietary intake, body composition (dual-energy X-ray absorptiometry/magnetic resonance imaging) and glucose/insulin indexes (oral glucose tolerance test (OGTT)/intravenous glucose tolerance test (IVGTT)) and inflammatory markers. Overall, N compared to C and N+ST reported significant improvements in SI (+16.5% vs. -32.3% vs. -6.9% respectively, P < 0.01) and disposition index (DI: +15.5% vs. -14.2% vs. -13.7% respectively, P < 0.01). N+ST compared to C and N reported significant reductions in hepatic fat fraction (HFF: -27.3% vs. -4.3% vs. 0% respectively, P < 0.01). Compared to N, N+ST reported reductions in plasminogen activator inhibitor-1 (PAI-1) (-38.3% vs. +1.0%, P < 0.01) and resistin (-18.7% vs. +11.3%, P = 0.02). There were no intervention effects for all other measures of adiposity or inflammation. Significant intervention by ethnicity interactions were found for African Americans in the N group who reported increases in total fat mass, 2-h glucose and glucose incremental areas under the curve (IAUC) compared to Latinos (P's < 0.05). These interventions yielded differential effects with N reporting favorable improvements in SI and DI and N+ST reporting marked reductions in HFF and inflammation. Both ethnic groups had significant improvements in metabolic health; however some improvements were not seen in African Americans.
dc.description.urihttp://dx.doi.org/10.1038/oby.2010.343
dc.identifierhttps://doi.org/10.13016/pohb-l86h
dc.identifier.citationHasson, Rebecca E. and Adam, Tanja C. and Davis, Jaimie N. and Kelly, Louise A. and Ventura, Emily E. and Byrd-Williams, Courtney E. and Toledo-Corral, Claudia M. and Roberts, Christian K. and Lane, Christianne J. and Azen, Stanley P. and Chou, Chih-Ping and Spruijt-Metz, Donna and Weigensberg, Mark J. and Berhane, Kiros and Goran, Michael I. (2011) Randomized Controlled Trial to Improve Adiposity, Inflammation, and Insulin Resistance in Obese African-American and Latino Youth. Obesity.
dc.identifier.issn1930-7381
dc.identifier.otherEprint ID 2539
dc.identifier.urihttp://hdl.handle.net/1903/23216
dc.subjectPrenatal & Pediatric Health
dc.subjectObesity
dc.subjectinterventions
dc.subjectResearch
dc.subjectinsulin sensitivity
dc.subjectmetabolic health
dc.titleRandomized Controlled Trial to Improve Adiposity, Inflammation, and Insulin Resistance in Obese African-American and Latino Youth
dc.typeArticle

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