Global Optimization of Cerebral Cortex Layout (I)

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dc.contributor.authorCherniak, Christopheren_US
dc.contributor.authorMokhtarzada, Zekeriaen_US
dc.contributor.authorRodriguez-Esteban, Raulen_US
dc.contributor.authorChangizi, B. K.en_US
dc.date.accessioned2004-05-31T23:33:14Z
dc.date.available2004-05-31T23:33:14Z
dc.date.created2003-10en_US
dc.date.issued2003-11-25en_US
dc.description.abstractFunctional areas of mammalian cerebral cortex seem positioned to minimize costs of their interconnections, down to a best-in-a-billion optimality level. The optimization problem here, originating in microcircuit design, is: Given connections among components, what is the physical placement of the components on a surface that minimizes total length of connections? Because of unfeasibility of measuring longrange "wirelength" in the cortex, a simpler adjacency cost was validated. To deal with incomplete information on brain networks, a Size Law was developed that predicts optimization patterns in subnetworks. Macaque and cat cortex rank better in this connection optimization than the wiring of comparably structured computer chips, but somewhat worse than the macroeconomic commodity-flow network among U.S. states. However, cortex wiring conforms to the Size Law better than the macroeconomic patterns, which may indicate cortex optimizing mechanisms involve more global processes. [ See also Supplementary Material: CS-TR-4535 ] UMIACS-TR-2003-102)en_US
dc.format.extent507643 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/1319
dc.language.isoen_US
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_US
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md.)en_US
dc.relation.isAvailableAtTech Reports in Computer Science and Engineeringen_US
dc.relation.isAvailableAtUMIACS Technical Reportsen_US
dc.relation.ispartofseriesUM Computer Science Department; CS-TR-4534en_US
dc.relation.ispartofseriesCS-TR-4535en_US
dc.relation.ispartofseriesUMIACS; UMIACS-TR-2003-102en_US
dc.titleGlobal Optimization of Cerebral Cortex Layout (I)en_US
dc.typeTechnical Reporten_US

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