Genome-wide association study identifies novel breast cancer susceptibility loci

dc.contributor.authorEaston, Douglas F.
dc.contributor.authorPooley, Karen A.
dc.contributor.authorDunning, Alison M.
dc.contributor.authorPharoah, Paul D. P.
dc.contributor.authorThompson, Deborah
dc.contributor.authorBallinger, Dennis G.
dc.contributor.authorStruewing, Jeffery P.
dc.contributor.authorMorrison, Jonathan
dc.contributor.authorField, Helen
dc.contributor.authorLuben, Robert
dc.contributor.authorWareham, Nicholas
dc.contributor.authorAhmed, Shahana
dc.contributor.authorHealey, Catherine S.
dc.contributor.authorBowman, Richard
dc.contributor.authorMeyer, Kerstin B.
dc.contributor.authorHaiman, Christopher A.
dc.contributor.authorKolonel, Laurence K.
dc.contributor.authorHenderson, Brian E.
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorBrennan, Paul
dc.contributor.authorSangrajrang, Suleeporn
dc.contributor.authorGaborieau, Valerie
dc.contributor.authorOdefrey, Fabrice
dc.contributor.authorShen, Chen-Yang
dc.contributor.authorWu, Pei-Ei
dc.contributor.authorWang, Hui-Chun
dc.contributor.authorEccles, Diana
dc.contributor.authorEvans, D. Gareth
dc.contributor.authorPeto, Julian
dc.contributor.authorFletcher, Olivia
dc.contributor.authorJohnson, Nichola
dc.contributor.authorSeal, Sheila
dc.contributor.authorStratton, Michael R.
dc.contributor.authorRahman, Nazneen
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorBojesen, Stig E.
dc.contributor.authorNordestgaard, Børge G.
dc.contributor.authorAxelsson, Christen K.
dc.contributor.authorGarcia-Closas, Montserrat
dc.contributor.authorBrinton, Louise
dc.contributor.authorChanock, Stephen
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorPeplonska, Beata
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorFagerholm, Rainer
dc.contributor.authorEerola, Hannaleena
dc.contributor.authorKang, Daehee
dc.contributor.authorYoo, Keun-Young
dc.contributor.authorNoh, Dong-Young
dc.contributor.authorAhn, Sei-Hyun
dc.contributor.authorHunter, David J.
dc.contributor.authorHankinson, Susan E.
dc.contributor.authorCox, David G.
dc.contributor.authorHall, Per
dc.contributor.authorWedren, Sara
dc.contributor.authorLiu, Jianjun
dc.contributor.authorLow, Yen-Ling
dc.contributor.authorBogdanova, Natalia
dc.contributor.authorSchu¨rmann, Peter
dc.contributor.authorDo¨rk, Do¨rk
dc.contributor.authorTollenaar, Rob A. E. M.
dc.contributor.authorJacobi, Catharina E.
dc.contributor.authorDevilee, Peter
dc.contributor.authorKlijn, Jan G. M.
dc.contributor.authorSigurdson, Alice J.
dc.contributor.authorDoody, Michele M.
dc.contributor.authorAlexander, Bruce H.
dc.contributor.authorZhang, Jinghui
dc.contributor.authorCox, Angela
dc.contributor.authorBrock, Ian W.
dc.contributor.authorMacPherson, Gordon
dc.contributor.authorReed, Malcolm W. R.
dc.contributor.authorCouch, Fergus J.
dc.contributor.authorGoode, Ellen L.
dc.contributor.authorOlson, Janet E.
dc.contributor.authorMeijers-Heijboer, Hanne
dc.contributor.authorvan den Ouweland, Ans
dc.contributor.authorUitterlinden, Andre´
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorMilne, Roger L.
dc.contributor.authorRibas, Gloria
dc.contributor.authorGonzalez-Neira, Anna
dc.contributor.authorBenitez, Javier
dc.contributor.authorHopper, John L.
dc.contributor.authorMcCredie, Margaret
dc.contributor.authorSouthey, Melissa
dc.contributor.authorGiles, Graham G.
dc.contributor.authorSchroen, Chris
dc.contributor.authorJustenhoven, Christina
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorHamann, Ute
dc.contributor.authorKo, Yon-Dschun
dc.contributor.authorSpurdle, Amanda B.
dc.contributor.authorBeesley, Jonathan
dc.contributor.authorChen, Xiaoqing
dc.contributor.authorkConFab, _
dc.contributor.authorthe SEARCH, collaborators
dc.contributor.authorAOCS, Management Group
dc.contributor.authorMannermaa, Arto
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorKataja, Vesa
dc.contributor.authorHartikainen, Jaana
dc.contributor.authorDay, Nicholas E.
dc.contributor.authorCox, David R.
dc.contributor.authorPonder, Bruce A. J.
dc.date.accessioned2019-08-14T15:00:09Z
dc.date.available2019-08-14T15:00:09Z
dc.date.issued2007
dc.description.abstractBreast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r2.0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P,1027). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P,0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach.
dc.description.urihttp://www.nature.com/nature/journal/v447/n7148/full/nature05887.html#abs
dc.identifierhttps://doi.org/10.13016/vuxu-r6kq
dc.identifier.citationEaston, Douglas F. and Pooley, Karen A. and Dunning, Alison M. and Pharoah, Paul D. P. and Thompson, Deborah and Ballinger, Dennis G. and Struewing, Jeffery P. and Morrison, Jonathan and Field, Helen and Luben, Robert and Wareham, Nicholas and Ahmed, Shahana and Healey, Catherine S. and Bowman, Richard and Meyer, Kerstin B. and Haiman, Christopher A. and Kolonel, Laurence K. and Henderson, Brian E. and Le Marchand, Loic and Brennan, Paul and Sangrajrang, Suleeporn and Gaborieau, Valerie and Odefrey, Fabrice and Shen, Chen-Yang and Wu, Pei-Ei and Wang, Hui-Chun and Eccles, Diana and Evans, D. Gareth and Peto, Julian and Fletcher, Olivia and Johnson, Nichola and Seal, Sheila and Stratton, Michael R. and Rahman, Nazneen and Chenevix-Trench, Georgia and Bojesen, Stig E. and Nordestgaard, Børge G. and Axelsson, Christen K. and Garcia-Closas, Montserrat and Brinton, Louise and Chanock, Stephen and Lissowska, Jolanta and Peplonska, Beata and Nevanlinna, Heli and Fagerholm, Rainer and Eerola, Hannaleena and Kang, Daehee and Yoo, Keun-Young and Noh, Dong-Young and Ahn, Sei-Hyun and Hunter, David J. and Hankinson, Susan E. and Cox, David G. and Hall, Per and Wedren, Sara and Liu, Jianjun and Low, Yen-Ling and Bogdanova, Natalia and Schu¨rmann, Peter and Do¨rk, Do¨rk and Tollenaar, Rob A. E. M. and Jacobi, Catharina E. and Devilee, Peter and Klijn, Jan G. M. and Sigurdson, Alice J. and Doody, Michele M. and Alexander, Bruce H. and Zhang, Jinghui and Cox, Angela and Brock, Ian W. and MacPherson, Gordon and Reed, Malcolm W. R. and Couch, Fergus J. and Goode, Ellen L. and Olson, Janet E. and Meijers-Heijboer, Hanne and van den Ouweland, Ans and Uitterlinden, Andre´ and Rivadeneira, Fernando and Milne, Roger L. and Ribas, Gloria and Gonzalez-Neira, Anna and Benitez, Javier and Hopper, John L. and McCredie, Margaret and Southey, Melissa and Giles, Graham G. and Schroen, Chris and Justenhoven, Christina and Brauch, Hiltrud and Hamann, Ute and Ko, Yon-Dschun and Spurdle, Amanda B. and Beesley, Jonathan and Chen, Xiaoqing and kConFab, _ and the SEARCH, collaborators and AOCS, Management Group and Mannermaa, Arto and Kosma, Veli-Matti and Kataja, Vesa and Hartikainen, Jaana and Day, Nicholas E. and Cox, David R. and Ponder, Bruce A. J. (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 447. pp. 1087-1093.
dc.identifier.otherEprint ID 707
dc.identifier.urihttp://hdl.handle.net/1903/22729
dc.subjectCancer
dc.subjectResearch
dc.subjectGenetics and Race
dc.subjectBreast cancer
dc.subjectgenetic susceptibility
dc.subjectfamilial risk
dc.subjectplausible causative genes
dc.titleGenome-wide association study identifies novel breast cancer susceptibility loci
dc.typeArticle

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