Genetic variability of smoking persistence in African Americans.

dc.contributor.authorHamidovic, Ajna
dc.contributor.authorKasberger, John L
dc.contributor.authorYoung, Taylor R
dc.contributor.authorGoodloe, Robert J
dc.contributor.authorRedline, Susan
dc.contributor.authorBuxbaum, Sarah G
dc.contributor.authorBenowitz, Neal L
dc.contributor.authorBergen, Andrew W
dc.contributor.authorButler, Kenneth R
dc.contributor.authorFranceschini, Nora
dc.contributor.authorGharib, Sina A
dc.contributor.authorHitsman, Brian
dc.contributor.authorLevy, Daniel
dc.contributor.authorMeng, Yan
dc.contributor.authorPapanicolaou, George J
dc.contributor.authorPreis, Sarah R
dc.contributor.authorSpring, Bonnie
dc.contributor.authorStyn, Mindi A
dc.contributor.authorTong, Elisa K
dc.contributor.authorWhite, Wendy B
dc.contributor.authorWiggins, Kerri L
dc.contributor.authorJorgenson, Eric
dc.description.abstractTo date, most genetic association analyses of smoking behaviors have been conducted in populations of European ancestry and many of these studies focused on the phenotype that measures smoking quantity, that is, cigarettes per day. Additional association studies in diverse populations with different linkage disequilibrium patterns and an alternate phenotype, such as total tobacco exposure which accounts for intermittent periods of smoking cessation within a larger smoking period as measured in large cardiovascular risk studies, can aid the search for variants relevant to smoking behavior. For these reasons, we undertook an association analysis by using a genotyping array that includes 2,100 genes to analyze smoking persistence in unrelated African American participants from the Atherosclerosis Risk in Communities study. A locus located approximately 4 kb downstream from the 3'-UTR of the brain-derived neurotrophic factor (BDNF) significantly influenced smoking persistence. In addition, independent variants rs12915366 and rs12914385 in the cluster of genes encoding nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4) on 15q25.1 were also associated with the phenotype in this sample of African American subjects. To our knowledge, this is the first study to more extensively evaluate the genome in the African American population, as a limited number of previous studies of smoking behavior in this population included evaluations of only single genomic regions.
dc.identifier.citationHamidovic, Ajna and Kasberger, John L and Young, Taylor R and Goodloe, Robert J and Redline, Susan and Buxbaum, Sarah G and Benowitz, Neal L and Bergen, Andrew W and Butler, Kenneth R and Franceschini, Nora and Gharib, Sina A and Hitsman, Brian and Levy, Daniel and Meng, Yan and Papanicolaou, George J and Preis, Sarah R and Spring, Bonnie and Styn, Mindi A and Tong, Elisa K and White, Wendy B and Wiggins, Kerri L and Jorgenson, Eric (2011) Genetic variability of smoking persistence in African Americans. Cancer prevention research (Philadelphia, Pa.), 4 (5). pp. 729-734.
dc.identifier.otherEprint ID 3049
dc.subjectSmoking & Tobacco Use
dc.subjectGenetics and Race
dc.subjectsmoking behaviors
dc.subjectsmoking cessation
dc.subjectcardiovascular risk studies
dc.titleGenetic variability of smoking persistence in African Americans.