Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche
dc.contributor.author | Patel, Akshay | |
dc.contributor.author | Wu, Yicong | |
dc.contributor.author | Han, Xiaofei | |
dc.contributor.author | Su, Yijun | |
dc.contributor.author | Maugel, Tim | |
dc.contributor.author | Shroff, Hari | |
dc.contributor.author | Roy, Sougata | |
dc.date.accessioned | 2022-06-14T15:38:09Z | |
dc.date.available | 2022-06-14T15:38:09Z | |
dc.date.issued | 2022-03-04 | |
dc.description | Partial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund. | en_US |
dc.description.abstract | Asymmetric signaling and organization in the stem-cell niche determine stem-cell fates. Here, we investigate the basis of asymmetric signaling and stem-cell organization using the Drosophila wing-disc that creates an adult muscle progenitor (AMP) niche. We show that AMPs extend polarized cytonemes to contact the disc epithelial junctions and adhere themselves to the disc/niche. Niche-adhering cytonemes localize FGF-receptor to selectively adhere to the FGF-producing disc and receive FGFs in a contact-dependent manner. Activation of FGF signaling in AMPs, in turn, reinforces disc-specific cytoneme polarity/adhesion, which maintains their disc-proximal positions. Loss of cytoneme-mediated adhesion promotes AMPs to lose niche occupancy and FGF signaling, occupy a disc-distal position, and acquire morphological hallmarks of differentiation. Niche-specific AMP organization and diversification patterns are determined by localized expression and presentation patterns of two different FGFs in the wing-disc and their polarized target-specific distribution through niche-adhering cytonemes. Thus, cytonemes are essential for asymmetric signaling and niche-specific AMP organization. | en_US |
dc.description.uri | https://doi.org/10.1038/s41467-022-28587-z | |
dc.identifier | https://doi.org/10.13016/mk39-lmr8 | |
dc.identifier.citation | Patel, A., Wu, Y., Han, X. et al. Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche. Nat Commun 13, 1185 (2022). | en_US |
dc.identifier.uri | http://hdl.handle.net/1903/28678 | |
dc.language.iso | en_US | en_US |
dc.publisher | Springer Nature | en_US |
dc.relation.isAvailableAt | Cell Biology & Molecular Genetics | en_us |
dc.relation.isAvailableAt | Digital Repository at the University of Maryland | en_us |
dc.relation.isAvailableAt | College of Computer, Mathematical & Natural Sciences | en_us |
dc.relation.isAvailableAt | University of Maryland (College Park, MD) | en_us |
dc.title | Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche | en_US |
dc.type | Article | en_US |
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