Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche

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dc.contributor.authorPatel, Akshay
dc.contributor.authorWu, Yicong
dc.contributor.authorHan, Xiaofei
dc.contributor.authorSu, Yijun
dc.contributor.authorMaugel, Tim
dc.contributor.authorShroff, Hari
dc.contributor.authorRoy, Sougata
dc.date.accessioned2022-06-14T15:38:09Z
dc.date.available2022-06-14T15:38:09Z
dc.date.issued2022-03-04
dc.descriptionPartial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.en_US
dc.description.abstractAsymmetric signaling and organization in the stem-cell niche determine stem-cell fates. Here, we investigate the basis of asymmetric signaling and stem-cell organization using the Drosophila wing-disc that creates an adult muscle progenitor (AMP) niche. We show that AMPs extend polarized cytonemes to contact the disc epithelial junctions and adhere themselves to the disc/niche. Niche-adhering cytonemes localize FGF-receptor to selectively adhere to the FGF-producing disc and receive FGFs in a contact-dependent manner. Activation of FGF signaling in AMPs, in turn, reinforces disc-specific cytoneme polarity/adhesion, which maintains their disc-proximal positions. Loss of cytoneme-mediated adhesion promotes AMPs to lose niche occupancy and FGF signaling, occupy a disc-distal position, and acquire morphological hallmarks of differentiation. Niche-specific AMP organization and diversification patterns are determined by localized expression and presentation patterns of two different FGFs in the wing-disc and their polarized target-specific distribution through niche-adhering cytonemes. Thus, cytonemes are essential for asymmetric signaling and niche-specific AMP organization.en_US
dc.description.urihttps://doi.org/10.1038/s41467-022-28587-z
dc.identifierhttps://doi.org/10.13016/mk39-lmr8
dc.identifier.citationPatel, A., Wu, Y., Han, X. et al. Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche. Nat Commun 13, 1185 (2022).en_US
dc.identifier.urihttp://hdl.handle.net/1903/28678
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtCell Biology & Molecular Geneticsen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtCollege of Computer, Mathematical & Natural Sciencesen_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.titleCytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor nicheen_US
dc.typeArticleen_US

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