The relationship between ciliary neurotrophic factor (CNTF) genotype and motor unit physiology: preliminary studies

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dc.contributor.authorConwit, Robin A
dc.contributor.authorLing, Shari
dc.contributor.authorRoth, Stephen
dc.contributor.authorStashuk, Daniel
dc.contributor.authorHurley, Ben
dc.contributor.authorFerrell, Robert
dc.contributor.authorMetter, E Jeffrey
dc.date.accessioned2021-12-09T15:31:37Z
dc.date.available2021-12-09T15:31:37Z
dc.date.issued2005-09-23
dc.description.abstractCiliary neurotrophic factor (CNTF) is important for neuronal and muscle development, and genetic variation in the CNTF gene has been associated with muscle strength. The effect of CNTF on nerve development suggests that CNTF genotype may be associated with force production via its influence on motor unit size and firing patterns. The purpose of this study is to examine whether CNTF genotype differentially affects motor unit activation in the vastus medialis with increasing isometric force during knee extension. Sixty-nine healthy subjects were genotyped for the presence of the G and A (null) alleles in the CNTF gene (n = 57 G/G, 12 G/A). They were tested using a dynamometer during submaximal isometric knee extension contractions that were from 10–50% of their maximal strength. During the contractions, the vastus medialis was studied using surface and intramuscular electromyography with spiked triggered averaging to assess surface-detected motor unit potential (SMUP) area and mean firing rates (mFR) from identified motor units. CNTF genotyping was performed using standard PCR techniques from DNA obtained from leucocytes of whole blood samples. The CNTF G/A genotype was associated with smaller SMUP area motor units and lower mFR at higher force levels, and fewer but larger units at lower force levels than G/G homozygotes. The two groups used motor units with different size and activation characteristics with increasing force generation. While G/G subjects tended to utilize larger motor units with increasing force, G/A subjects showed relatively less increase in size by using relatively larger units at lower force levels. At higher force levels, G/A subjects were able to generate more force per motor unit size suggesting more efficient motor unit function with increasing muscle force. Differential motor unit responses were observed between CNTF genotypes at force levels utilized in daily activities.en_US
dc.description.urihttps://doi.org/10.1186/1472-6793-5-15
dc.identifierhttps://doi.org/10.13016/oxhh-qcld
dc.identifier.citationConwit, R.A., Ling, S., Roth, S. et al. The relationship between ciliary neurotrophic factor (CNTF) genotype and motor unit physiology: preliminary studies. BMC Physiol 5, 15 (2005).en_US
dc.identifier.urihttp://hdl.handle.net/1903/28223
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtSchool of Public Healthen_us
dc.relation.isAvailableAtKinesiologyen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectFiring Rateen_US
dc.subjectMotor Uniten_US
dc.subjectMaximal Voluntary Contractionen_US
dc.subjectKnee Extensoren_US
dc.subjectForce Levelen_US
dc.titleThe relationship between ciliary neurotrophic factor (CNTF) genotype and motor unit physiology: preliminary studiesen_US
dc.typeArticleen_US

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