Randomized Control Trial to Improve Adiposity and Insulin Resistance in Overweight Latino Adolescents

Simple item page
dc.contributor.authorDavis, Jaimie N.
dc.contributor.authorKelly, Louise A.
dc.contributor.authorLane, Christianne J.
dc.contributor.authorVentura, Emily E.
dc.contributor.authorByrd-Williams, Courtney E.
dc.contributor.authorAlexandar, Katharine A.
dc.contributor.authorAzen, Stanley P.
dc.contributor.authorChou, Chih-Ping
dc.contributor.authorSpruijt-Metz, Donna
dc.contributor.authorWeigensberg, Marc J.
dc.contributor.authorBerhane, Kiros
dc.contributor.authorGoran, Michael I.
dc.date.accessioned2019-08-14T15:02:23Z
dc.date.available2019-08-14T15:02:23Z
dc.date.issued2009
dc.description.abstractFew randomized trials attempt to improve insulin sensitivity and associated metabolic risks in overweight Latino youth. The purpose of this study is to examine the effects of a modified carbohydrate nutrition program combined with strength training on insulin sensitivity, adiposity, and other type 2 diabetes risk factors in overweight Latino adolescents. In a 16-week randomized trial, 54 overweight Latino adolescents (15.5 +/- 1.0 years) were randomly assigned to: (i) Control (C; n = 16), (ii) Nutrition (N; n = 21), or (iii) Nutrition + Strength training (N+ST; n = 17). The N group received modified carbohydrate nutrition classes (once per week), while the N+ST received the same nutrition classes plus strength training (twice per week). The following were measured at pre- and postintervention: strength by 1-repetition maximum, dietary intake by 3-day records, body composition by dual-energy X-ray absorptiometry, glucose/insulin indices by oral glucose tolerance test (OGTT) and intravenous glucose tolerance test with minimal modeling. Across intervention group effects were tested using analysis of covariance with post hoc pairwise comparisons. A significant overall intervention effect was found for improvement in bench press (P < 0.001) and reductions in energy (P = 0.05), carbohydrate (P = 0.04) and fat intake (P = 0.03). There were no significant intervention effects on insulin sensitivity, body composition, or most glucose/insulin indices with the exception of glucose incremental area under the curve (IAUC) (P = 0.05), which decreased in the N and N+ST group by 18 and 6.3% compared to a 32% increase in the C group. In conclusion, this intense, culturally tailored intervention resulted in no significant intervention effects on measured risk factors with the exception of a beneficial effect on glycemic response to oral glucose.
dc.description.urihttp://dx.doi.org/10.1038/oby.2009.19
dc.identifierhttps://doi.org/10.13016/6x3z-bqpl
dc.identifier.citationDavis, Jaimie N. and Kelly, Louise A. and Lane, Christianne J. and Ventura, Emily E. and Byrd-Williams, Courtney E. and Alexandar, Katharine A. and Azen, Stanley P. and Chou, Chih-Ping and Spruijt-Metz, Donna and Weigensberg, Marc J. and Berhane, Kiros and Goran, Michael I. (2009) Randomized Control Trial to Improve Adiposity and Insulin Resistance in Overweight Latino Adolescents. Obesity, 17 (8). pp. 1542-1548.
dc.identifier.issn1930-7381
dc.identifier.otherEprint ID 2540
dc.identifier.urihttp://hdl.handle.net/1903/23217
dc.subjectPrenatal & Pediatric Health
dc.subjectDiabetes
dc.subjectObesity
dc.subjectHealth Risk Factors
dc.subjectstudies
dc.subjectinsulin sensitivity
dc.subjectmetabolic risk
dc.subjectoverweight Latino youth
dc.subjectglycemic response
dc.titleRandomized Control Trial to Improve Adiposity and Insulin Resistance in Overweight Latino Adolescents
dc.typeArticle

Files

Collections

Minority Health and Health Equity Archive