Genetic Structure, Self-Identified Race/Ethnicity, and Confounding in Case-Control Association Studies

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dc.contributor.authorTang, Hua
dc.contributor.authorQuertermous, Tom
dc.contributor.authorRodriguez, Beatriz
dc.contributor.authorKardia, Sharon LR
dc.contributor.authorZhu, Xiaofeng
dc.contributor.authorBrown, Andrew
dc.contributor.authorPankow, James S
dc.contributor.authorProvince, Michael A
dc.contributor.authorHunt, Steven C
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorSchork, Nicholas J
dc.contributor.authorRisch, Neil J
dc.date.accessioned2019-08-14T14:59:26Z
dc.date.available2019-08-14T14:59:26Z
dc.date.issued2005
dc.description.abstractWe have analyzed genetic data for 326 microsatellite markers that were typed uniformly in a large multiethnic population-based sample of individuals as part of a study of the genetics of hypertension (Family Blood Pressure Program). Subjects identified themselves as belonging to one of four major racial/ethnic groups (white, African American, East Asian, and Hispanic) and were recruited from 15 different geographic locales within the United States and Taiwan. Genetic cluster analysis of the microsatellite markers produced four major clusters, which showed near-perfect correspondence with the four self-reported race/ethnicity categories. Of 3,636 subjects of varying race/ethnicity, only 5 (0.14%) showed genetic cluster membership different from their self-identified race/ethnicity. On the other hand, we detected only modest genetic differentiation between different current geographic locales within each race/ethnicity group. Thus, ancient geographic ancestry, which is highly correlated with self-identified race/ethnicity—as opposed to current residence—is the major determinant of genetic structure in the U.S. population. Implications of this genetic structure for case-control association studies are discussed.
dc.description.urihttp://www.sciencedirect.com/science/article/pii/S0002929707625786
dc.identifierhttps://doi.org/10.13016/i1sx-opbr
dc.identifier.citationTang, Hua and Quertermous, Tom and Rodriguez, Beatriz and Kardia, Sharon LR and Zhu, Xiaofeng and Brown, Andrew and Pankow, James S and Province, Michael A and Hunt, Steven C and Boerwinkle, Eric and Schork, Nicholas J and Risch, Neil J (2005) Genetic Structure, Self-Identified Race/Ethnicity, and Confounding in Case-Control Association Studies. Am J Hum Genet, 76. pp. 268-275.
dc.identifier.otherEprint ID 479
dc.identifier.urihttp://hdl.handle.net/1903/22572
dc.subjectHypertension
dc.subjectstudies
dc.subjectGenetics and Race
dc.subjectgenetic structure
dc.subjectrace
dc.subjectethnicity
dc.subjectconfounding
dc.subjectcase-control association studies
dc.subjecthypertension
dc.titleGenetic Structure, Self-Identified Race/Ethnicity, and Confounding in Case-Control Association Studies
dc.typeArticle

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