dc.contributor.author | Kingsford, Carl | |
dc.contributor.author | Delcher, Arthur L. | |
dc.contributor.author | Salzberg, Steven L. | |
dc.date.accessioned | 2008-06-05T19:15:58Z | |
dc.date.available | 2008-06-05T19:15:58Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes. C. Kingsford, A.L. Delcher, and S.L. Salzberg. Molec. Biol. and Evol 24:9 (2007), 2091-98. | en |
dc.identifier.uri | http://hdl.handle.net/1903/7986 | |
dc.description.abstract | Overlapping genes are a common phenomenon. Among sequenced prokaryotes, more than 29% of all annotated genes
overlap at least 1 of their 2 flanking genes. We present a unified model for the creation and repair of overlaps among
adjacent genes where the 3# ends either overlap or nearly overlap. Our model, derived from a comprehensive analysis of
complete prokaryotic genomes in GenBank, explains the nonuniform distribution of the lengths of such overlap regions
far more simply than previously proposed models. Specifically, we explain the distribution of overlap lengths based on
random extensions of genes to the next occurring downstream stop codon. Our model also provides an explanation for
a newly observed (here) pattern in the distribution of the separation distances of closely spaced nonoverlapping genes.
We provide evidence that the newly described biased distribution of separation distances is driven by the same
phenomenon that creates the uneven distribution of overlap lengths. This suggests a dynamic picture of continual overlap
creation and elimination. | en |
dc.format.extent | 224856 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | en |
dc.publisher | Molecular Biology and Evolution | en |
dc.subject | genome analysis | en |
dc.subject | gene finding | en |
dc.subject | overlapping genes | en |
dc.subject | prokaryotes | en |
dc.title | A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes. | en |
dc.type | Article | en |
dc.relation.isAvailableAt | College of Computer, Mathematical & Physical Sciences | en_us |
dc.relation.isAvailableAt | Computer Science | en_us |
dc.relation.isAvailableAt | Digital Repository at the University of Maryland | en_us |
dc.relation.isAvailableAt | University of Maryland (College Park, MD) | en_us |