The past 10-15 years have seen numerous calls for curricular reform in undergraduate biology education, most of which focus on changes to curriculum or pedagogy. Data collected from students in a large introductory undergraduate biology course indicate that student expectations about the nature of the knowledge they were learning influence how they interacted with reform efforts in that class. Given that student expectations influence the ways in which they participate in course activities, this paper (the first in a series that looks at student expectations in biology) argues that curriculum reform initiatives should consider student expectations in order to increase the chance for effective implementation.