Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men
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Date
2006
Authors
Freedman, Matthew L.
Haiman, Christopher A.
Patterson, Nick
McDonald, Gavin J.
Tandon, Arti
Waliszewska, Alicja
Penney, Kathryn
Steen, Robert G.
Kristin Ardlie, Kristin
John, Esther M.
Advisor
Citation
Freedman, Matthew L. and Haiman, Christopher A. and Patterson, Nick and McDonald, Gavin J. and Tandon, Arti and Waliszewska, Alicja and Penney, Kathryn and Steen, Robert G. and Kristin Ardlie, Kristin and John, Esther M. and Oakley-Girvan, Ingrid and Whittemore, Alice S. and Cooney, Kathleen A. and Ingles, Sue A. and Altshuler, David and Henderson, Brian E. and Reich, David (2006) Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. PNAS, 103 (38). pp. 14068-14073.
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Abstract
A whole-genome admixture scan in 1,597 African Americans identified a 3.8Mbinterval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD)7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age (P < 0.00032) and may contribute to the epidemiological observation that the higher risk for prostate cancer in African Americans is greatest in younger men (and attenuates with older age). The same region was recently identified through linkage analysis of prostate cancer, followed by fine-mapping. We strongly replicated this association (P<4.2109) but find that the previously described alleles do not explain more than a fraction of the admixture signal. Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it.