To identify the most appropriate scientific areas to address in this plan, the Institute drew from its existing research portfolio aimed at eliminating health disparities. Reflecting the Institute’s mission, the unifying concept of the plan is development, starting before conception and continuing throughout the lifespan and across generations. The Institute’s long experience investigating the complex biological and environmental interactions that drive developmental processes is invaluable when clarifying the causes of racial, ethnic, and even community-based disparities. By focusing and coordinating research on gestation and the early years of life, including the transitions into and out of adolescence and young adulthood, the NICHD can address not only the development of health disparities, but the critical timing of preventive and therapeutic strategies.