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    Body Maps on Human Chromosomes

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    UMIACS-TR-2015-04.pdf (719.7Kb)
    No. of downloads: 226

    Date
    2015-11-08
    Author
    Cherniak, Christopher
    Rodriguez-Esteban, Raul
    DRUM DOI
    https://doi.org/10.13016/M2MM73
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    Abstract
    An exploration of the hypothesis that human genes are organized somatotopically: For each autosomal chromosome, its tissue-specific genes tend to have relative positions on the chromosome that mirror corresponding positions of the tissues in the body. In addition, there appears to be a division of labor: Such a homunculus representation on a chromosome holds significantly for either the anteroposterior or the dorsoventral body axis. In turn, anteroposterior and dorsoventral chromosomes tend to occupy separate zones in the spermcell nucleus. One functional rationale of such largescale organization is for efficient interconnections in the genome.
    URI
    http://hdl.handle.net/1903/17177
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