Cell Biology & Molecular Genetics
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STRATEGIES AND RESOURCES FOR RATIONAL VACCINE DESIGN AND ANTIBODY-ANTIGEN DOCKING AND AFFINITY PREDICTION
(2022)Antibody recognition of antigens is a unique class of protein-protein interactions, and increased knowledge regarding the determinants of these interactions has advanced fields such as computational vaccine design and ... -
MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
(2022)The human airway epithelium represents the primary site of infection for many respiratory viruses, including influenza A virus (IAV). To safeguard this tissue and maintain the functionality of the lung, humans possess a ... -
KEEPING IT IN FRAME: MONITORING RIBOSOMAL FRAMESHIFTING DURING TRANSLATION
(2022)Programmed -1 ribosomal frameshifting (-1 PRF) is a molecular mechanism that redirects translating ribosomes into a new reading frame. It is widely used by RNA viruses to conserve genome space while expanding the viral ... -
INVESTIGATION OF ACCELERATED SKIN AGING AND PEROXISOMAL ABNORMALITIES IN HUTCHINSON-GILFORD PROGERIA SYNDROME
(2022)Hutchinson-Gilford progeria syndrome (HGPS) is a detrimental premature aging disease caused by a point mutation in human LMNA gene. This mutation results in the abnormal accumulation of a truncated pre-lamin A protein ... -
Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche
(Springer Nature, 2022-03-04)Asymmetric signaling and organization in the stem-cell niche determine stem-cell fates. Here, we investigate the basis of asymmetric signaling and stem-cell organization using the Drosophila wing-disc that creates an adult ...