Global, Environmental, and Occupational Health

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Prior to May 2024, previously known as the Maryland Institute for Applied Environmental Health.

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    NEW METHODOLOGY TO IDENTIFY POTENTIAL ENVIRONMENTAL TRIGGERS FOR ANCA-ASSOCIATED VASCULITIDES
    (2018) Beins, Kaley Elizabeth; Milton, Donald K.; Maryland Institute for Applied Environmental Health; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    A series of rare autoimmune disorders that affect the blood vessels, vasculitis is chronic and potentially deadly. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprise three diagnostic forms of this autoimmune disorder: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA or Churg-Strauss syndrome). The limited resources available to vasculitis researchers have been mostly targeted toward treatment and relapse prediction with a small amount of research examining genetic and environmental etiologic factors. Therefore, additional research is needed to understand the role of gene-environment interactions in AAV etiology. This thesis reviews the current body of AAV literature with a focus on candidate genes, occupational and environmental exposures, and the hygiene hypothesis. It also designs an original survey and study methodology to further investigate these etiologic factors. A better understanding of AAV etiology will lead to prevention and improved treatment of these costly diseases.
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    Should We Put Our Feet in the Water? Use of a Survey to Assess Recreational Exposures to Contaminants in the Anacostia River
    (Libertas Academica, 2015-04-29) Murray, Rianna; Wilson, Sacoby; Dalemarre, Laura; Chanse, Victoria; Phoenix, Janet; Baranoff, Lori
    The Anacostia River, a tributary of the Potomac River that flows into the Chesapeake Bay, is highly contaminated with raw sewage, heavy metals, oil and grease, trash, pathogens, excessive sediments, and organic chemicals. Despite this contamination, recreation on the river is very popular, including kayaking, canoeing, rowing, and sport fishing. There is currently no information available on the potential health risks faced by recreational users from exposure to the river’s pollutants. A total of 197 recreational users of the Anacostia River were surveyed regarding general demographic information and their recreational behavior over the previous year, including frequency and duration of recreation and specific questions related to their water exposure. 84.1% of respondents who engaged in canoeing, kayaking, rowing, rafting, or paddling were exposed to water on their bodies during recreation. Some 27.2% of those exposed to water reported getting water in their mouth while recreating, and 60.7% of that group reported swallowing some of this water. This is the first study to examine the exposure to contaminants faced by the recreational population of the Anacostia River.
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    Variability of organophosphorous pesticide metabolite levels in spot and 24-hr urine samples collected from young children during 1 week.
    (2013-01) Bradman, Asa; Kogut, Katherine; Eisen, Ellen A.; Jewell, Nicholas; Quiros-Alcala, Lesliam; Castorina, Rosemary; Chevrier, Jonathan; Holland, Nina T.; Barr, Dana B.; Kavanagh-Baird, Gerry; Eskenazi, Brenda
    Background: Dialkyl phosphate (DAP) metabolites in spot urine samples are frequently used to characterize children’s exposures to organophosphorous (OP) pesticides. However, variable exposure and short biological half-lives of OP pesticides could result in highly variable measurements, leading to exposure misclassification. Objective: We examined within- and between-child variability in DAP metabolites in urine samples collected during 1 week. Methods: We collected spot urine samples over 7 consecutive days from 25 children (3–6 years of age). On two of the days, we collected 24-hr voids. We assessed the reproducibility of urinary DAP metabolite concentrations and evaluated the sensitivity and specificity of spot urine samples as predictors of high (top 20%) or elevated (top 40%) weekly average DAP metabolite concentrations. Results: Within-child variance exceeded between-child variance by a factor of two to eight, depending on metabolite grouping. Although total DAP concentrations in single spot urine samples were moderately to strongly associated with concentrations in same-day 24-hr samples (r ≈ 0.6–0.8, p < 0.01), concentrations in spot samples collected > 1 day apart and in 24-hr samples collected 3 days apart were weakly correlated (r ≈ –0.21 to 0.38). Single spot samples predicted high (top 20%) and elevated (top 40%) full-week average total DAP excretion with only moderate sensitivity (≈ 0.52 and ≈ 0.67, respectively) but relatively high specificity (≈ 0.88 and ≈ 0.78, respectively). Conclusions: The high variability we observed in children’s DAP metabolite concentrations suggests that single-day urine samples provide only a brief snapshot of exposure. Sensitivity analyses suggest that classification of cumulative OP exposure based on spot samples is prone to type 2 classification errors.