Tech Reports in Computer Science and Engineering

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Author: search.filters.author.Cherniak, ChristopherStart date: 2020

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    Nervous system maps on the C. elegans genome
    (2020-09-28) Cherniak, Christopher; Mokhtarzada, Zekeria; Rodriguez-Esteban, Raul
    This project begins from a synoptic point of view, focusing upon the large-scale (global) landscape of the genome. This is along the lines of combinatorial network optimization in computational complexity theory [1]. Our research program here in turn originated along parallel lines in computational neuroanatomy [2,3,4,5]. Rather than mapping body structure onto the genome, the present report focuses upon statistically significant mappings of the Caenorhabditis elegans nervous system onto its genome. Via published datasets, evidence is derived for a "wormunculus", on the model of a homunculus representation, but on the C. elegans genome. The main method of testing somatic-genomic position-correlations here is via public genome databases, with r^2 analyses and p evaluations. These findings appear to yield some of the basic structural and functional organization of invertebrate nucleus and chromosome architecture. The design rationale for somatic maps on the genome in turn may be efficient interconnections. A next question this study raises: How do these various somatic maps mesh (interrelate, interact) with each other?