Theses and Dissertations from UMD

Permanent URI for this communityhttp://hdl.handle.net/1903/2

New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM

More information is available at Theses and Dissertations at University of Maryland Libraries.

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    Multiple Testing Procedures for the Analysis of Microarray Data
    (2013) Nuriely, Ayala; Smith, Paul J; Mathematics; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    We reviewed literature about various multiple testing techniques, especially addressing microarray analyses and small sample sizes, and reanalyzed data from Yuen et al. (Physiological Genomics, 2006) which compared the effect of HgCl2 and Ischemia/Reperfusion injuries on rat kidney tissues. Our analysis uses only 22 rats with small numbers of rats in each treatment group, and 9,501 genes under study. We used empirical Bayes (EB) and permutation testing (implemented in Bioconductor) in an effort to identify differentially expressed genes. EB identified a large number of genes as differentially expressed, including both previously identified and newly identified genes. The newly identified genes appear to have biological functions similar to those previously identified. We also recognized power differences between EB and permutation tests, possibly due to nonnormality of the data but also because permutation tests do not make use of all available information in the data.