Theses and Dissertations from UMD
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New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM
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Item AN INITIAL EVALUATION OF IBI VIZEDIT: AN RSHINY APPLICATION FOR OBTAINING ACCURATE ESTIMATES OF AUTONOMIC REGULATION OF CARDIAC ACTIVITY(2018) Barstead, Matthew; Rubin, Kenneth H; Human Development; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)Photoplethysmogram (PPG) sensors are increasingly used to collect individual heart rate data during laboratory assessments and psychological experiments. PPG sensors are relatively cheap, easy to use, and non-invasive alternatives to the more common electrodes used to produce electrocardiogram recordings. The downside is that these sensors are more susceptible to signal distortion. Often, the most relevant measures for understanding psychological processes that underlie emotions and behaviors are measures of heart rate variability. As with all measures of variability, outliers (i.e., signal artifacts) can have outsized effects on the final estimates; and, given that these scores represent a primary variable of interest in many research contexts, the successful elimination of artefactual points is critical to the ability to make valid inferences with the data. Prior to the development of IBI VizEdit, there was no single, integrated processing and editing pipeline for PPG data. The present pair of studies offers and initial evaluation of the program’s performance. Study 1 is focused on the efficacy of a novel approach to imputing sections of particularly corrupted PPG signal. Study 2 tests the ability of trained editors to reliably use IBI VizEdit as well as the validity of estimates of cardiac activity during a prescribed set of laboratory tasks. Study 1 suggests that the novel imputation approach, under certain conditions and using certain parameterizations may hold promise as a means of accurately imputing missing sections of data. However, Study 1 also clearly demonstrates the need for further refinement and the consideration of alternative implementations. The results from Study 2 indicate that IBI VizEdit can be reliably used by trained editors and that estimates of cardiac activity derived from its output are likely valid.Item Experimentally Testing the Effect of Parent-Adolescent Conflict on HIV Risk, and Investigation of a Neurobiological Moderator of This Effect(2015) Thomas, Sarah Ann; De Los Reyes, Andres; Psychology; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)Human immunodeficiency virus (HIV) is a condition in which immune cells become destroyed such that the body may become unable to fight off infections. Engaging in risk-taking behaviors (e.g., substance use) puts people at heightened risk for HIV infection, with mid-to-late adolescents at increasing risk (Leigh & Stall, 1993). Environmental and neurological reasons have been suggested for increased risk-taking among adolescents. First, family-level precursors such as parent-adolescent conflict have been significantly associated with and may pose risk for engaging in substance use and risk-taking (Duncan, Duncan, Biglan, & Ary, 1998). Thus, parent-adolescent conflict may be an important proximal influence on HIV risk behaviors (Lester et al., 2010; Rowe, Wang, Greenbaum, & Liddle, 2008). Yet, the temporal relation between parent-adolescent conflict and adolescent HIV risk-taking behaviors is still unknown. Second, at-risk adolescents may carry a neurobiological predisposition for engaging in trait-like expressions of disinhibited behavior and other risk-taking behaviors (Iacono, Malone, & McGue, 2008). When exposed to interpersonally stressful situations, their likelihood of engagement in HIV risk behaviors may increase. To investigate the role of parent-adolescent conflict in adolescent HIV risk-taking behaviors, 49 adolescents ages 14-17 and their parent were randomly assigned to complete a standardized discussion task to discuss a control topic or a conflict topic. Immediately after the discussion, adolescents completed a laboratory risk-taking measure. In a follow-up visit, eligible adolescents underwent electrophysiological (EEG) recording while completing a task designed to assess the presence of a neurobiological marker for behavioral disinhibition which I hypothesized would moderate the links between conflict and risk-taking. First, findings indicated that during the discussion task, adolescents in the conflict condition evidenced a significantly greater psychophysiological stress response relative to adolescents in the control condition. Second, a neurobiological marker of behavioral disinhibition moderated the relation between discussion condition and adolescent risk-taking, such that adolescents evidencing relatively high levels of a neurobiological marker related to sensation-seeking evidenced greater levels of risk-taking following the conflict condition, relative to the control condition. Lastly, I observed no significant relation between parent-adolescent conflict, the neurobiological marker of behavioral disinhibition and adolescent engagement in real-world risk-taking behavior.Item The Relationship Between Physical Activity and Executive Control Functioning as Modified by Genotype(2007-08-03) Hearn, Joe W.; Hatfield, Bradley D.; Kinesiology; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)As we age, the structure of the brain deteriorates and cognitive functioning declines. The region of the brain that begins to age the fastest is the frontal lobe, in which the dorsal-lateral prefrontal cortex is involved in executive control functions such as planning, organizing, initiating behaviors, and working memory. For some individuals, the brain declines more rapidly with age because of genetic factors. Apolipoprotein E (APOE) is a gene that assists in the transport of cholesterol and repair of the brain when it is damaged. Presence of the ε4 allele impairs cholesterol transport and puts its carriers at risk for increased cognitive decline and possibly dementia of the Alzheimer's type (DAT). Physical activity can slow the aging process of the brain and delay the onset and severity of cognitive decline and DAT as it increases oxygenation and blood flow, neuronal growth and synaptogenesis, and it increases the expression of genes helpful to the functioning of the brain such as brain-derived neurotrophic factor (BDNF). Therefore, individuals at greater genetic risk for age-related cognitive decline (i.e., ε4 carriers) should receive increased benefit from physical activity. Accordingly, this study examined the relationship between physical activity and executive control functioning, assessed by the Wisconsin Card Sort Test (WCST) in middle-aged APOE ε4 carriers and non-carriers. High-active participants were predicted to perform better than their low-active counterparts, and this difference should be even greater among APOE ε4 carriers. While most research studies on this topic have focused on general cognitive performance, the present study is specific in its focus on executive control functioning. Sixty-seven cognitively normal middle-aged adults between the ages of 50 - 70 years were assessed on medical history, overall cognitive functioning, APOE genotype, level of physical activity, and executive control functioning (WCST). Using hierarchical regression, seven WCST variables were regressed on age, genotype, physical activity, and the interaction between genotype and physical activity. Analysis revealed that as level of physical activity increased, performance significantly improved on all seven WCST variables for APOE ε4 carriers, but not for non-carriers. These results reveal that the benefits of physical activity to cognitive performance in this age group are specific to those who are genetically at-risk for cognitive decline.