Theses and Dissertations from UMD

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New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM

More information is available at Theses and Dissertations at University of Maryland Libraries.

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Author: search.filters.author.Xu, YanruiSubject: search.filters.subject.lung cancer

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    Anti-cancer mechanism of arctigenin (ARC) in human lung cancer cells
    (2018) Xu, Yanrui; Lee, Seong-Ho; Nutrition; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Arctigenin (ARC) is a lignan and is abundant in Asteraceae plant which possesses anti-inflammatory and anti-cancer activities. The current study was performed to investigate if ARC affects cancer progression and metastasis focusing on epithelial–mesenchymal transition (EMT) using invasive human lung cancer cell line, A549. No toxicity was observed in the cells treated with different doses of ARC (12-100 µM). The treatment of ARC repressed TGF-β-stimulated changes of metastatic morphology and cell invasion and migration. ARC inhibited TGF-β-induced phosphorylation and transcriptional activity of SMAD2/3 and expression of snail in dose-dependent and time-dependent manners. ARC also decreased expression of N-cadherin and increased expression of E-cadherin in dose-dependent and time-dependent manners. These changes were accompanied with decreased amount of nuclear phospho-SMAD2 and SMAD3, and nuclear translocation of SMAD2 and SMAD3. Moreover, ARC repressed TGF-β-induced phosphorylation of ERK. Our data demonstrate anti-metastatic activity of ARC in lung cancer model. Key words: ARC, TGF-β, EMT, Lung cancer