Theses and Dissertations from UMD

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New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM

More information is available at Theses and Dissertations at University of Maryland Libraries.

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Author: search.filters.author.Withuhn, Thomas Frederick

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    The Effects of Neonatal Oxytocin on Sexual Maturation and the Expression of Sociosexual Reproductive Behavior in Female Rats
    (2004-09-27) Withuhn, Thomas Frederick; Cushing, Bruce S; Biology; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    While the role of OT in regulating adult behavior data is thoroughly documented, increasing evidence suggests that neonatal exposure to OT can have long-term effects on behavior and physiology. Based upon the role of OT in regulating adult behavior, I predicted that neonatal OT would affect the expression of adult female sociosexual behavior and sexual maturation. Female Sprague-Dawley rats were treated for the first 7 days of life with intraperitoneal injections of either OT (1 mg/g), an OT antagonist (0.1 mg/g), isotonic saline, or handled only. Parameters measured included age of vaginal opening, age of first estrus, a 10-hr paced sex test during first estrus, and body weight on postnatal days 70, 91 and 136. Treatment with OT significantly delayed the age of vaginal opening and first estrus. OTA significantly reduced mating frequency from an expected rate of 33%. There was no effect on weight at any age.