Theses and Dissertations from UMD

Permanent URI for this communityhttp://hdl.handle.net/1903/2

New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM

More information is available at Theses and Dissertations at University of Maryland Libraries.

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Author: search.filters.author.Shurer, Andrew Joseph

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    Efforts Toward Synthesis of Novel Analogs of the Bacterial Second-Messenger, c-di-GMP
    (2009) Shurer, Andrew Joseph; Sintim, Herman O; Chemistry; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    The formation of bacterial biofilms is a common mechanism for antibiotic resistance. It has been shown that bis-(3'-5')-cyclic dimeric guanosine monophosphate, c-di-GMP, plays a key role in bacterial biofilm formation; therefore, the proteins that regulate the metabolism or adaptive response of c-di-GMP are favorable targets for novel antimicrobials. We herein describe a solid-support methodology developed in the Sintim Laboratory and efforts toward its application to the synthesis of novel c-di-GMP analogs. Our selected targets are a series of analogs bearing various substitutions at the 2'-position of the ribose backbone. Syntheses of 2'-deoxy and 2'-methoxy analogs were achieved as well as that of key intermediates toward the 2'-fluoro and conformationally flexible analogs.