Theses and Dissertations from UMD

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New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM

More information is available at Theses and Dissertations at University of Maryland Libraries.

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Author: search.filters.author.Mejia-Guevara, YasminSubject: search.filters.subject.Biology

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    The Importance of Transfer Receptor 1 in Adipose Tissue
    (2021) Mejia-Guevara, Yasmin; Kim, Byung-Eun; Animal Sciences; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Iron homeostasis is essential for maintaining cellular function in a variety of cell types. Transferrin receptor 1 (TfR1), which is expressed ubiquitously, facilitates cellular iron (Fe) uptake through receptor-mediated endocytosis of Fe-loaded transferrin. This study was undertaken to evaluate the importance of TfR1-mediated Fe import into adipose tissues for thermogenesis and systemic metabolism. We found that adipose-specific TfR1 knockout mice exhibited severe cold susceptibility upon acute cold exposure, leading to death of the mutant mice within hours. This phenotype was exacerbated by dietary Fe limitation and partially rescued by Fe administration. Knockout mice showed marked defects in oxidative phosphorylation components and lipid droplet homeostasis in adipose tissues. Furthermore, elevated levels of plasma glucose and insulin in the mutant’s hint at an unexpected connection between adipocyte Fe deficiency and diabetes. Altogether, our results suggest that TfR1-mediated Fe uptake is critical for multiple aspects of adipose function and systemic energy metabolism.