Theses and Dissertations from UMD

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New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM

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Author: search.filters.author.Johnnie, Joseph GeorgeSubject: search.filters.subject.Metabolic Engineering

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    A Systems Engineering Framework for Metabolic Engineering Experiments
    (2011) Johnnie, Joseph George; Austin, Mark; Systems Engineering; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Cells of living organisms simultaneously operate hundreds or thousands of interconnected chemical reactions. Metabolic networks include these chemical reactions and compounds participating in them. Metabolic engineering is a science centered on the analysis and purposeful modification of an organism's metabolic network toward a beneficial purpose, such as production of fuel or medicinal compounds in microorganisms. Unfortunately, there are problems with the design and visualization of modified metabolic networks due to lack of standardized and fully developed visual modeling languages. The purposes of this paper are to propose a multilevel framework for the synthesis, analysis and design of metabolic systems, and then explore the extent to which abstractions from systems engineering (e.g., SysML) can complement and add value to the abstractions currently under development within the greater biological community (e.g., SBGN). The computational test-bed that accompanies this work is production of the anti-malarial drug artemisinin in genetically engineered Saccaharomyces cerevisiae (yeast).