Theses and Dissertations from UMD

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New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM

More information is available at Theses and Dissertations at University of Maryland Libraries.

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Author: search.filters.author.Dutta, BhaskarSubject: search.filters.subject.Biology, Plant Physiology

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    TIME SERIES TRANSCRIPTIONAL PROFILING ANALYSIS OF THE Arabidopsis thaliana USING FULL GENOME DNA MICROARRAY AND METABOLIC INFORMATION
    (2004-08-26) Dutta, Bhaskar; Klapa, Maria I; Quackenbush, John; Chemical Engineering; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    With the advent of the DNA microarray technology, it became possible to study the expression of entire cellular genomes. Tanscriptional profiling alone can not provide a comprehensive picture of the cellular physiological state and it should be complemented by other cellular fingerprints. Transcriptional profiling combined with metabolic information of a systematically perturbed system can unravel the relationship between gene and metabolic regulation. In this context the transcriptional response of Arabidopsis thaliana liquid cultures (grown for 12 days under light and 23 sup oC) to 1-day treatment with 1% CO sub 2 was measured by full genome cDNA microarrays. The Time series gene expression profiles were analyzed in the context of the known Arabidopsis thaliana physiology using multivariate statistics. Data analysis revealed an increase in the rate of CO sub 2 fixation, biomass production and cell wall growth. The breadth of the information obtained from a single experiment validated the significance of the high throughput transcriptional profiling.