Theses and Dissertations from UMD

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New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM

More information is available at Theses and Dissertations at University of Maryland Libraries.

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Author: search.filters.author.Dougherty, MeganSubject: search.filters.subject.Salmonella

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    The Role of CheV in S. typhimurium Chemotaxis
    (2006-12-11) Dougherty, Megan; Stewart, Richard C; Cell Biology & Molecular Genetics; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    The chemotaxis systems of Escherichia coli and Salmonella typhimurium are thought to be virtually identical. However, recently a putative chemotaxis gene, cheV, was found to be present in S. typhimurium but not in E. coli. Sequence analysis shows that the CheV protein shares sequence similarity to both CheW and CheY. My thesis research investigated whether cheV does play a role in S. typhimurium chemotaxis. My results show that disruption of the cheV gene had no effect on S. typhimurium's swarming ability and only a minor effect on the ability of S. typhimurium to sense/respond to serine and its ability to accomplish surface motility. My results also indicate that overexpression of the cheV gene disrupts S. typhimurium's swarming ability, as well as, S. typhimurium's ability to sense/respond to serine and S. typhimurium's ability to accomplish surface motility. Overall, these results suggest that CheV may be involved in S. typhimurium chemotaxis.