(Genome Biology, 2008-01) Haas, Brian U.; Salzberg, Steven L.; Zhu, Wei; Pertea, Mihaela; Allen, Jonathan E.; Orvis, Joshua; White, Owen; Buell, C Robin; Wortman, Jennifer R
EVidenceModeler (EVM) is presented as an automated eukaryotic gene structure annotation tool
that reports eukaryotic gene structures as a weighted consensus of all available evidence. EVM,
when combined with the Program to Assemble Spliced Alignments (PASA), yields a comprehensive,
configurable annotation system that predicts protein-coding genes and alternatively spliced
isoforms. Our experiments on both rice and human genome sequences demonstrate that EVM
produces automated gene structure annotation approaching the quality of manual curation.
