Browsing by Author "Duvall, Bridget Rebecca"
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Item EFFORTS TOWARD (+)-7-DEOXYPANCRATISTATIN FEATURING A PALLADIUM CATALYZED ALLYLIC ARYLATION(2005-01-21) Duvall, Bridget Rebecca; DeShong, Philip R.; Chemistry; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)The synthesis of pancratistatin, 7-deoxypancratistatin, and its analogs have attracted the interest of synthetic chemists due to both their structural complexity as well as interesting biological activity. Although previous syntheses have been reported, a general and efficient route to produce multigram quantities of these compounds has remained elusive. Herein is described a general approach to this class of compounds. The optimized route is reported. All work towards effecting and understanding the key allylic arylation reaction is described.