A Systems Engineering Framework for Metabolic Engineering Experiments

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dc.contributor.advisorAustin, Marken_US
dc.contributor.authorJohnnie, Joseph Georgeen_US
dc.contributor.departmentSystems Engineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2012-02-17T07:00:25Z
dc.date.available2012-02-17T07:00:25Z
dc.date.issued2011en_US
dc.description.abstractCells of living organisms simultaneously operate hundreds or thousands of interconnected chemical reactions. Metabolic networks include these chemical reactions and compounds participating in them. Metabolic engineering is a science centered on the analysis and purposeful modification of an organism's metabolic network toward a beneficial purpose, such as production of fuel or medicinal compounds in microorganisms. Unfortunately, there are problems with the design and visualization of modified metabolic networks due to lack of standardized and fully developed visual modeling languages. The purposes of this paper are to propose a multilevel framework for the synthesis, analysis and design of metabolic systems, and then explore the extent to which abstractions from systems engineering (e.g., SysML) can complement and add value to the abstractions currently under development within the greater biological community (e.g., SBGN). The computational test-bed that accompanies this work is production of the anti-malarial drug artemisinin in genetically engineered <italic>Saccaharomyces cerevisiae </italic> (yeast).en_US
dc.identifier.urihttp://hdl.handle.net/1903/12332
dc.subject.pqcontrolledSystem scienceen_US
dc.subject.pqcontrolledChemical engineeringen_US
dc.subject.pqcontrolledSystematic biologyen_US
dc.subject.pquncontrolledArtemisininen_US
dc.subject.pquncontrolledFlux Balance Analysisen_US
dc.subject.pquncontrolledMetabolic Engineeringen_US
dc.subject.pquncontrolledNetwork Biologyen_US
dc.subject.pquncontrolledSBGNen_US
dc.subject.pquncontrolledSysMLen_US
dc.titleA Systems Engineering Framework for Metabolic Engineering Experimentsen_US
dc.typeThesisen_US

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