Interference of Apoptosis by Hepatitis B Virus

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dc.contributor.authorLin, Shaoli
dc.contributor.authorZhang, Yan-Jin
dc.date.accessioned2018-06-29T14:39:14Z
dc.date.available2018-06-29T14:39:14Z
dc.date.issued2017-08-18
dc.descriptionPartial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.en_US
dc.description.abstractHepatitis B virus (HBV) causes liver diseases that have been a consistent problem for human health, leading to more than one million deaths every year worldwide. A large proportion of hepatocellular carcinoma (HCC) cases across the world are closely associated with chronic HBV infection. Apoptosis is a programmed cell death and is frequently altered in cancer development. HBV infection interferes with the apoptosis signaling to promote HCC progression and viral proliferation. The HBV-mediated alteration of apoptosis is achieved via interference with cellular signaling pathways and regulation of epigenetics. HBV X protein (HBX) plays a major role in the interference of apoptosis. There are conflicting reports on the HBV interference of apoptosis with the majority showing inhibition of and the rest reporting induction of apoptosis. In this review, we described recent studies on the mechanisms of the HBV interference with the apoptosis signaling during the virus infection and provided perspective.en_US
dc.identifierhttps://doi.org/10.13016/M2TQ5RH5G
dc.identifier.citationLin, S.; Zhang, Y.-J. Interference of Apoptosis by Hepatitis B Virus. Viruses 2017, 9, 230; doi:10.3390/v9080230en_US
dc.identifier.urihttp://hdl.handle.net/1903/20685
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtDepartment of Veterinary Medicineen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjecthepatitis B virus (HBV)en_US
dc.subjectapoptosisen_US
dc.subjecthepatocellular carcinoma (HCC)en_US
dc.subjectX proteinen_US
dc.titleInterference of Apoptosis by Hepatitis B Virusen_US
dc.typeArticleen_US

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