Differences in clinical characteristics and disease-free survival for Latino, African American, and non-Latino white men with localized prostate cancer

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dc.contributor.authorLatini, David M.
dc.contributor.authorElkin, Eric P.
dc.contributor.authorCooperberg, Matthew R.
dc.contributor.authorSadetsky, Natalia
dc.contributor.authorDuChane, Janeen
dc.contributor.authorCarroll, Peter R.
dc.date.accessioned2019-08-14T15:03:34Z
dc.date.available2019-08-14T15:03:34Z
dc.date.issued2006
dc.description.abstractBACKGROUND: Few studies of ethnicity and prostate cancer have included Latino men in analyses of baseline clinical characteristics, treatment selection, and disease-free survival (DFS). The present study examines the impact of Latino ethnicity on these parameters in a large, multiinstitutional database of men with prostate cancer. METHODS: We compared baseline disease characteristics and clinical outcomes for Latino (N = 138), non-Latino White (NLW, N = 5619), and African-American (AA, N = 608) men with localized prostate cancer by using chi-square and ANOVA for baseline variables and survival analysis to examine differences in time to recurrence. RESULTS: Latino men resembled AA men more than NLW on sociodemographic characteristics. AA men had higher Gleason scores and prostate-specific antigen (PSA) at diagnosis than Latino or NLW men (both P < 0.01). 10% of both Latino and AA men presented with advanced disease (T3b/T4/N+/M+) versus 4% of NLW (P < 0.01). Latino men did not receive different treatments than NLW or AA men after controlling for clinical and demographic factors; however, AA men were more likely to receive external beam radiation (OR = 1.51, 95% confidence interval [CI] = 0.99-2.31) and hormone treatment (OR = 1.56, 95% CI = 1.05-2.32) then NLW men. For prostatectomy patients, 3-year actuarial DFS rates were 83% for NLW men and 86% for Latino men versus 69% for AA men (P < 0.01). After controlling for clinical and sociodemographic variables, AA men were somewhat more likely than NLW to experience disease recurrence after radical prostatectomy (RP) (HR = 1.38, 95% CI = 0.98-1.94, P = 0.06). CONCLUSIONS: Latinos are more similar to African Americans on sociodemographic characteristics but more similar to NLW on clinical presentation, treatments received, and DFS.
dc.description.urihttp://dx.doi.org/10.1002/cncr.21675
dc.identifierhttps://doi.org/10.13016/v8cw-drtb
dc.identifier.citationLatini, David M. and Elkin, Eric P. and Cooperberg, Matthew R. and Sadetsky, Natalia and DuChane, Janeen and Carroll, Peter R. (2006) Differences in clinical characteristics and disease-free survival for Latino, African American, and non-Latino white men with localized prostate cancer. Cancer, 106 (4). pp. 789-795.
dc.identifier.issn0008-543X
dc.identifier.otherEprint ID 2854
dc.identifier.urihttp://hdl.handle.net/1903/23494
dc.subjectCancer
dc.subjectstudies
dc.subjectprostatic neoplasms
dc.subjectethnicity
dc.subjectlongitudinal analysis
dc.titleDifferences in clinical characteristics and disease-free survival for Latino, African American, and non-Latino white men with localized prostate cancer
dc.typeArticle

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