The Potentials of Methylene Blue as an Anti-Aging Drug

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dc.contributor.authorXue, Huijing
dc.contributor.authorThaivalappil, Abhirami
dc.contributor.authorCao, Kan
dc.date.accessioned2023-10-27T18:56:08Z
dc.date.available2023-10-27T18:56:08Z
dc.date.issued2021-12-01
dc.description.abstractMethylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. Apart from its well-known applications in surgical staining, malaria, and methemoglobinemia, the anti-oxidative properties of MB recently brought new attention to this century-old drug. Mitochondrial dysfunction has been observed in systematic aging that affects many different tissues, including the brain and skin. This leads to increaseding oxidative stress and results in downstream phenotypes under age-related conditions. MB can bypass Complex I/III activity in mitochondria and diminish oxidative stress to some degree. This review summarizes the recent studies on the applications of MB in treating age-related conditions, including neurodegeneration, memory loss, skin aging, and a premature aging disease, progeria.
dc.description.urihttps://doi.org/10.3390/cells10123379
dc.identifierhttps://doi.org/10.13016/dspace/ezr3-smel
dc.identifier.citationXue, H.; Thaivalappil, A.; Cao, K. The Potentials of Methylene Blue as an Anti-Aging Drug. Cells 2021, 10, 3379.
dc.identifier.urihttp://hdl.handle.net/1903/31172
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtCell Biology & Molecular Geneticsen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtCollege of Computer, Mathematical & Natural Sciencesen_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectmethylene blue
dc.subjectmitochondria
dc.subjectneurodegeneration
dc.subjectskin aging
dc.subjectprogeria
dc.titleThe Potentials of Methylene Blue as an Anti-Aging Drug
dc.typeArticle
local.equitableAccessSubmissionNo

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