TopHat-Fusion: an algorithm for discovery of novel fusion transcripts
| dc.contributor.author | Kim, Daehwan | |
| dc.contributor.author | Salzberg, Steven L | |
| dc.date.accessioned | 2013-01-10T20:37:47Z | |
| dc.date.available | 2013-01-10T20:37:47Z | |
| dc.date.issued | 2011-08-11 | |
| dc.description.abstract | TopHat-Fusion is an algorithm designed to discover transcripts representing fusion gene products, which result from the breakage and re-joining of two different chromosomes, or from rearrangements within a chromosome. TopHat-Fusion is an enhanced version of TopHat, an efficient program that aligns RNA-seq reads without relying on existing annotation. Because it is independent of gene annotation, TopHat-Fusion can discover fusion products deriving from known genes, unknown genes and unannotated splice variants of known genes. Using RNA-seq data from breast and prostate cancer cell lines, we detected both previously reported and novel fusions with solid supporting evidence. TopHat-Fusion is available at http://tophat-fusion.sourceforge.net/. | en_US |
| dc.description.uri | https://doi.org/10.1186/gb-2011-12-8-r72 | |
| dc.identifier.citation | Kim, D., Salzberg, S.L. TopHat-Fusion: an algorithm for discovery of novel fusion transcripts. Genome Biol 12, R72 (2011). | en_US |
| dc.identifier.uri | http://hdl.handle.net/1903/13349 | |
| dc.language.iso | en_US | en_US |
| dc.relation.isAvailableAt | College of Computer, Mathematical & Natural Sciences | en_us |
| dc.relation.isAvailableAt | Computer Science | en_us |
| dc.relation.isAvailableAt | Digital Repository at the University of Maryland | en_us |
| dc.relation.isAvailableAt | University of Maryland (College Park, MD) | en_us |
| dc.subject | TopHat-Fusion | en_US |
| dc.subject | algorithm | en_US |
| dc.subject | usion gene products | en_US |
| dc.subject | TopHat | en_US |
| dc.subject | RNA-seq | en_US |
| dc.title | TopHat-Fusion: an algorithm for discovery of novel fusion transcripts | en_US |
| dc.type | Article | en_US |