Chitosan to Connect Biology to Electronics: Fabricating the Bio-Device Interface and Communicating Across This Interface

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dc.contributor.authorKim, Eunkyoung
dc.contributor.authorXiong, Yuan
dc.contributor.authorCheng, Yi
dc.contributor.authorWu, Hsuan-Chen
dc.contributor.authorLiu, Yi
dc.contributor.authorMorrow, Brian H.
dc.contributor.authorBen-Yoav, Hadar
dc.contributor.authorGhodssi, Reza
dc.contributor.authorRubloff, Gary W.
dc.contributor.authorShen, Jana
dc.contributor.authorBentley, William E.
dc.contributor.authorShi, Xiaowen
dc.contributor.authorPayne, Gregory F.
dc.date.accessioned2024-01-11T21:35:02Z
dc.date.available2024-01-11T21:35:02Z
dc.date.issued2014-12-24
dc.description.abstractIndividually, advances in microelectronics and biology transformed the way we live our lives. However, there remain few examples in which biology and electronics have been interfaced to create synergistic capabilities. We believe there are two major challenges to the integration of biological components into microelectronic systems: (i) assembly of the biological components at an electrode address, and (ii) communication between the assembled biological components and the underlying electrode. Chitosan possesses a unique combination of properties to meet these challenges and serve as an effective bio-device interface material. For assembly, chitosan’s pH-responsive film-forming properties allow it to “recognize” electrode-imposed signals and respond by self-assembling as a stable hydrogel film through a cathodic electrodeposition mechanism. A separate anodic electrodeposition mechanism was recently reported and this also allows chitosan hydrogel films to be assembled at an electrode address. Protein-based biofunctionality can be conferred to electrodeposited films through a variety of physical, chemical and biological methods. For communication, we are investigating redox-active catechol-modified chitosan films as an interface to bridge redox-based communication between biology and an electrode. Despite significant progress over the last decade, many questions still remain which warrants even deeper study of chitosan’s structure, properties, and functions.
dc.description.urihttps://doi.org/10.3390/polym7010001
dc.identifierhttps://doi.org/10.13016/dspace/x6wi-xhje
dc.identifier.citationKim, E.; Xiong, Y.; Cheng, Y.; Wu, H.-C.; Liu, Y.; Morrow, B.H.; Ben-Yoav, H.; Ghodssi, R.; Rubloff, G.W.; Shen, J.; et al. Chitosan to Connect Biology to Electronics: Fabricating the Bio-Device Interface and Communicating Across This Interface. Polymers 2015, 7, 1-46.
dc.identifier.urihttp://hdl.handle.net/1903/31579
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtA. James Clark School of Engineeringen_us
dc.relation.isAvailableAtFischell Department of Bioengineeringen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectbioelectronics
dc.subjectbiofabrication
dc.subjectbiosensing
dc.subjectcatechol
dc.subjectchitosan
dc.subjectelectrochemistry
dc.subjectelectrodeposition
dc.subjectredox-activity
dc.subjectredox-capacitor
dc.subjecttyrosinase
dc.titleChitosan to Connect Biology to Electronics: Fabricating the Bio-Device Interface and Communicating Across This Interface
dc.typeArticle
local.equitableAccessSubmissionNo

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