INVESTIGATING THE INTERACTIONS BETWEEN BIOPOLYMERS AND BLOOD VIA OPTICAL MICROSCOPY

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dc.contributor.advisorRaghavan, Srinivasa Ren_US
dc.contributor.authorMacIntire, Ian Collinsen_US
dc.contributor.departmentChemical Engineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2015-09-18T05:38:54Z
dc.date.available2015-09-18T05:38:54Z
dc.date.issued2015en_US
dc.description.abstractHydrophobically modified (hm) derivatives of biopolymers such as chitosan have been shown to convert liquid blood into an elastic gel. This interesting material property could make hm-chitosan (hmC) useful as a hemostatic agent in treating severe bleeding. In this work, we attempted to probe the mechanism of action of hmC by studies on mixtures of blood cells and hmC using optical microscopy. Our results show that the presence of hydrophobic tails on hmC induces significant clustering of blood cells. We show that clustering increases as the fraction of hydrophobic tails on hmC increases, length of the hydrophobic tails increases, and as concentration of hmC increases. Finally, clustering due to hmC could be reversed by the addition of the supramolecule a-cyclodextrin, which is known to capture hydrophobes in its binding pocket. The results from this work support the earlier mechanism, with a few important modifications.en_US
dc.identifierhttps://doi.org/10.13016/M2F06Z
dc.identifier.urihttp://hdl.handle.net/1903/16944
dc.language.isoenen_US
dc.subject.pqcontrolledEngineeringen_US
dc.titleINVESTIGATING THE INTERACTIONS BETWEEN BIOPOLYMERS AND BLOOD VIA OPTICAL MICROSCOPYen_US
dc.typeThesisen_US

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