A MATHEMATICAL MODEL TO STUDY THE ROLE OF THE LSR INTERGENIC REGION IN MEDIATION OF AUTOINDUCER-2 QUORUM SENSING IN ESCHERICHIA COLI

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dc.contributor.advisorBentley, William E.en_US
dc.contributor.authorGraff, Steven Meyeren_US
dc.contributor.departmentBioengineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2014-02-06T06:31:46Z
dc.date.available2014-02-06T06:31:46Z
dc.date.issued2013en_US
dc.description.abstractQuorum sensing (QS) is a process that allows bacteria to communicate with each other to coordinate collective behavior in response to changes in environmental conditions. Their ability to mediate biofilm formation of biofilms and antibiotic resistance has created challenges on healthcare systems, and an impetus for us to understand QS systems. QS mediated by autoinducer-2 is likely to be the most common of these mechanisms. Recent work has elaborated on the LuxS-regulated (Lsr) system which can mediate and process AI-2 to QS-dependent behaviors, particularly regulatory elements including the lsr intergenic region and the repressor LsrR, the so-called QS"switch". In this thesis, we present a simulation of an example lsr-QS-system to elucidate the role of the lsr intergenic region binding site interactions and how this model integrates with recent literature on LsrR's protein structure to provide further details on the mechanisms of how the switch may operate in real systems.en_US
dc.identifier.urihttp://hdl.handle.net/1903/14845
dc.language.isoenen_US
dc.subject.pqcontrolledBiomedical engineeringen_US
dc.subject.pqcontrolledSystematic biologyen_US
dc.subject.pqcontrolledMathematicsen_US
dc.subject.pquncontrolledautoinducer-2en_US
dc.subject.pquncontrolledlsr intergenic regionen_US
dc.subject.pquncontrolledLsrRen_US
dc.subject.pquncontrolledLsrR tetrameren_US
dc.subject.pquncontrolledmathematical modelen_US
dc.subject.pquncontrolledquorum sensingen_US
dc.titleA MATHEMATICAL MODEL TO STUDY THE ROLE OF THE LSR INTERGENIC REGION IN MEDIATION OF AUTOINDUCER-2 QUORUM SENSING IN ESCHERICHIA COLIen_US
dc.typeThesisen_US

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