Electrospun Small-Diameter Silk Fibroin Vascular Grafts with Tuned Mechanical and Biocompatibility Properties as Tissue Engineered Scaffolds

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dc.contributor.advisorHsieh, Adam H.
dc.contributor.authorAl-Salihi, Mina
dc.contributor.authorBerger, Adam G.
dc.contributor.authorDang, Megan N.
dc.contributor.authorJones, Irene
dc.contributor.authorKarsalia, Moli
dc.contributor.authorLim, Casey G.
dc.contributor.authorMenachery, Sherin M.
dc.contributor.authorMgboji, Glory
dc.contributor.authorNou, Angelina
dc.contributor.authorSingleterry, Marquise
dc.contributor.authorSrinivasan, Devayani
dc.contributor.authorTran, Phillip
dc.contributor.authorZhou, Amy
dc.date.accessioned2017-08-15T16:44:51Z
dc.date.available2017-08-15T16:44:51Z
dc.date.issued2017
dc.description.abstractAlmost 9 million people in the U.S. have peripheral arterial disease (PAD). In severe cases of PAD, arterial bypass surgery is performed to redirect flow around the problem area. However, for many elderly patients, this surgery is not feasible using the preferred autologous grafts because of the limited availability of tissue to use for grafting, so there is a clinical need for engineered vascular grafts. Engineered grafts are intended to replace native blood vessels by manipulating biomaterials to mimic the properties of the native vessel. Despite success in large diameter cases, small diameter grafts are still prone to a number of issues such as occlusion, hyperplasia, and thrombosis. Silk fibroin is a promising biomaterial for creating vascular grafts because of its demonstrated mechanical strength and biocompatibility. Our research established a method for electrospinning the silk fibroin onto a rotating mandrel for seamless grafts. Mechanical testing, including burst pressure and tensile strength tests, compared the strength of our grafts to that of the autologous vessel. Finally, biochemical modifications, aimed at both recruiting and proliferating HUVECs on the grafts, increased cell proliferation on the grafts in vitro.en_US
dc.identifierhttps://doi.org/10.13016/M2SN0144G
dc.identifier.urihttp://hdl.handle.net/1903/19619
dc.language.isoen_USen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)
dc.subjectGemstone Team VESSELen_US
dc.titleElectrospun Small-Diameter Silk Fibroin Vascular Grafts with Tuned Mechanical and Biocompatibility Properties as Tissue Engineered Scaffoldsen_US
dc.typeThesisen_US

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