Peroxisomal-microsomal communication in unsaturated fatty acid metabolism

Simple item page
dc.contributor.authorBaykousheva, Svetla P.
dc.contributor.authorLuthria, Devanand L.
dc.contributor.authorSprecher, Howard
dc.date.accessioned2011-08-04T17:42:26Z
dc.date.available2011-08-04T17:42:26Z
dc.date.issued1995
dc.description.abstractThe addition of 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to peroxisomes decreased the production of acid-soluble radioactivity formed by β-oxidation of [1-14C]arachidonate due to substrate removal by esterification into the acceptor. This peroxisomal-associated acyl-CoA:1-acyl-GPC acyltransferase activity was due to microsomal contamination. The production of acid-soluble radioactivity from [1-14C]7,10,13,16–22:4, but not from [3-14C]7,10,13,16–22:4 was independent of 1-acyl-GPC, with and without microsomes. By comparing rates of peroxisomal β-oxidation with those for microsomal acylation, it was shown that the preferred metabolic fate of arachidonate, when added directly to incubations, or generated via β-oxidation, was esterification by microsomal 1-acyl-GPC acyltransferase, rather than continued peroxisomal β-oxidation.en_US
dc.identifier.citationBaykousheva, Svetla P, Luthria, Devanand L, and Sprecher, Howard.1995. Peroxisomal-microsomal communication in unsaturated fatty acid metabolism. FEBS Letters 367 (2):198-200.en_US
dc.identifier.urihttp://hdl.handle.net/1903/11823
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland Librariesen_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectMicrosomeen_US
dc.subjectAcylationen_US
dc.subjectPeroxisomeen_US
dc.subjectArachidonic aciden_US
dc.subject7,10,13,16-Docosatetraenoic aciden_US
dc.subjectβ-Oxidationen_US
dc.subjectBeta-oxidationen_US
dc.subjectFatty acidsen_US
dc.subjectBaykouchevaen_US
dc.titlePeroxisomal-microsomal communication in unsaturated fatty acid metabolismen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Baykousheva_FEBS Lett_1995.PDF
Size:
323.79 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.57 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Library Faculty/Staff Scholarship and Research