POLICY POINTS: Upstream factors—social structures/systems, cultural factors, and pub-lic policy—are primary forces that drive downstream patterns and in-equities in health that are observed across race and locations. A public policy agenda that aims to address inequities related to thewell-being of children, creation and perpetuation of residential segre-gation, and racial segregation can address upstream factors. Past successes and failures provide a blueprint for addressing upstreamhealth issues and inhibit health equity.