An Optical Density Detection Platform with Integrated Microfluidics for In Situ Growth, Monitoring, and Treatment of Bacterial Biofilms

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dc.contributor.advisorGhodssi, Rezaen_US
dc.contributor.authorMosteller, Matthew Philipen_US
dc.contributor.departmentSystems Engineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2013-04-09T05:31:58Z
dc.date.available2013-04-09T05:31:58Z
dc.date.issued2012en_US
dc.description.abstractSystems engineering strategies utilizing platform-based design methodologies are implemented to achieve the integration of biological and physical system components in a biomedical system. An application of this platform explored, in which an integrated microsystem is developed capable of the on-chip growth, monitoring, and treatment of bacterial biofilms for drug development and fundamental study applications. In this work, the developed systems engineering paradigm is utilized to develop a device system implementing linear array charge-coupled devices to enable real time, non-invasive, label-free monitoring of bacterial biofilms. A novel biofilm treatment method is demonstrated within the developed microsystem showing drastic increases in treatment efficacy by decreasing both bacterial biomass and cell viability within treated biofilms. Demonstration of this treatment at the microscale enables future applications of this method for the in vivo treatment of biofilm-associated infections.en_US
dc.identifier.urihttp://hdl.handle.net/1903/13862
dc.subject.pqcontrolledBiomedical engineeringen_US
dc.subject.pqcontrolledElectrical engineeringen_US
dc.subject.pqcontrolledSystem scienceen_US
dc.subject.pquncontrolledBacterial Biofilmen_US
dc.subject.pquncontrolledBioelectric Effecten_US
dc.subject.pquncontrolledLab on a Chipen_US
dc.subject.pquncontrolledMicrofluidicen_US
dc.subject.pquncontrolledOptical Densityen_US
dc.subject.pquncontrolledSystems Engineeringen_US
dc.titleAn Optical Density Detection Platform with Integrated Microfluidics for In Situ Growth, Monitoring, and Treatment of Bacterial Biofilmsen_US
dc.typeThesisen_US

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