The researcher investigated how the personality traits of sensation seeking, anxiety, and self-confidence are associated with AIDS-related sexual risk-taking of college students. It was hypothesized that individuals who exhibited high levels of sensation seeking, low anxiety, and low self-confidence in specific domains would participate in a significant amount of sexual risk-taking. If this were true, then preventive approaches could be geared toward helping risk-takers cope with the characteristics that place them at-risk. The researcher administered the following measures to 313 college students: the Sensation Seeking Scale Form V (SSS V), the Endler Multidimensional Anxiety Scales-Trait (EMAS-T), the Personal Evaluation Inventory (PEI), a modified Sexual Behavior Questionnaire, and a demographic questionnaire. Two aspects of sensation seeking (Disinhibition and Boredom Susceptibility) on the SSS V were significantly associated with AIDS-related sexual risk-taking. High sensation seekers engaged in more sexual risk-taking than low sensation seekers in these areas. In addition, moderate sexual risk-takers only exhibited less anxiety than low risk-takers in the Daily Routines aspect of anxiety on the EMAS-T. Moderate risk-takers displayed greater self-confidence regarding Romantic Relationships than low risk-takers on the PEI. The association between sensation seeking and anxiety was negative. High sexual risk-takers showed a greater worry about getting AIDS and higher perception of AIDS risk than low sexual risk-takers. No gender differences were found in sexual risk-taking. Implications for research included conducting studies regarding sensation seeking and AIDS-related sexual behavior with gay and lesbian college students, and with individuals of college age not attending college. Studies measuring the psychometric qualities of the SSS V and the PEI were also suggested. A practical outcome of this study was the proposed use of an updated measure to assess participation in novel, varied, and risky activities. Clinicians could employ this measure in public schools and college counseling centers, under certain circumstances.