This dissertation examines the impact of cancer on financial outcomes for individuals aged 50 and older and documents how this relationship varies by sex and race/ethnicity. I then turn to the impact of depression on out-of-pocket medical spending among those with a history of cancer. Findings suggest cancer can have a deleterious effect on the financial outcomes of those who are diagnosed with cancer. Out-of-pocket spending rises in the year of diagnosis, reduced earnings persist beyond diagnosis, and depression increases out-of-pocket spending. I fail to find evidence that the relationship between cancer and financial outcomes is moderated by sex or race-ethnicity.