Impact of Cryptosporidium spp. interaction with co-occurring microorganisms on moderate-to-severe diarrhea in the developing world

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dc.contributor.advisorSapkota, Amy Ren_US
dc.contributor.authorReid, Molly Carrollen_US
dc.contributor.departmentMaryland Institute for Applied Environmental Healthen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2016-06-22T05:32:15Z
dc.date.available2016-06-22T05:32:15Z
dc.date.issued2015en_US
dc.description.abstractDiarrheal illness is responsible for over a quarter of all deaths in children under 5 years of age in sub-Saharan Africa and South Asia. Recent findings have identified the parasite Cryptosporidium as a contributor to enteric disease. We examined 9,348 cases and 13,128 controls from the Global Enteric Multicenter Study to assess whether Cryptosporidium interacted with co-occurring pathogens based on adjusted odds of moderate-to-severe diarrhea (MSD). Cryptosporidium was found to interact negatively with Shigella spp., with multiplicative interaction score of 0.16 (95% CI: 0.07 to 0.37, p-value=0.000), and an additive interaction score of -9.81 (95% CI: -13.61 to -6.01, p-value=0.000). Cryptosporidium also interacted negatively with Aeromonas spp., Adenovirus, Norovirus, and Astrovirus with marginal significance. Odds of MSD for Cryptosporidium co-infection with Shigella spp., Aeromonas spp., Adenovirus, Norovirus, or Astrovirus are lower than odds of MSD with either organism alone. This may reduce the efficacy of intervention strategies targeted at Cryptosporidium.en_US
dc.identifierhttps://doi.org/10.13016/M25F5K
dc.identifier.urihttp://hdl.handle.net/1903/18120
dc.language.isoenen_US
dc.subject.pqcontrolledEpidemiologyen_US
dc.subject.pqcontrolledEnvironmental healthen_US
dc.subject.pqcontrolledBiostatisticsen_US
dc.subject.pquncontrolledCryptosporidiumen_US
dc.subject.pquncontrolledEntericen_US
dc.subject.pquncontrolledGEMSen_US
dc.subject.pquncontrolledInteractionen_US
dc.subject.pquncontrolledPolymicrobialen_US
dc.subject.pquncontrolledShigellaen_US
dc.titleImpact of Cryptosporidium spp. interaction with co-occurring microorganisms on moderate-to-severe diarrhea in the developing worlden_US
dc.typeThesisen_US

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