ROLE OF PROJECTIONS FROM ORBITOFRONTAL CORTEX TO DORSAL STRIATUM IN INCUBATION OF OXYCDONE CRAVING

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dc.contributor.advisorLi, Xuanen_US
dc.contributor.authorLin, Hongyuen_US
dc.contributor.departmentPsychologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2024-02-10T06:36:16Z
dc.date.available2024-02-10T06:36:16Z
dc.date.issued2023en_US
dc.description.abstractOxycodone seeking progressively increases during abstinence and maintains for an extended period, a phenomenon termed incubation of oxycodone craving. We previously found that the orbitofrontal cortex (OFC) plays a causal role in this incubation. Here, we aimed to identify critical downstream regions of OFC in incubation of oxycodone craving by focusing on the central to medial portion of the dorsal striatum (DS), based on previous anatomical evidence. We first measured projection-specific activation on abstinence day 15 seeking test by using cholera toxin b (retrograde tracer, injected into DS) +Fos (activity marker) double-labeling in the OFC. Next, we determined the effect of pharmacological reversible inactivation of DS on incubated oxycodone seeking on abstinence day 15. We then used an anatomical asymmetrical disconnection procedure to determine whether OFC to DS projections contribute to incubated oxycodone seeking.en_US
dc.identifierhttps://doi.org/10.13016/dspace/lyok-fov5
dc.identifier.urihttp://hdl.handle.net/1903/31677
dc.language.isoenen_US
dc.subject.pqcontrolledNeurosciencesen_US
dc.subject.pqcontrolledCognitive psychologyen_US
dc.subject.pqcontrolledBiologyen_US
dc.subject.pquncontrolledDorsal striatumen_US
dc.subject.pquncontrolledDrug addictionen_US
dc.subject.pquncontrolledOrbitofrontal cortexen_US
dc.subject.pquncontrolledOxycodone relapseen_US
dc.titleROLE OF PROJECTIONS FROM ORBITOFRONTAL CORTEX TO DORSAL STRIATUM IN INCUBATION OF OXYCDONE CRAVINGen_US
dc.typeThesisen_US

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