Solid oxide fuel cells (SOFCs) are a highly efficient chemical to electrical energy conversion devices that have potential in a global energy strategy. The wide adoption of SOFCs is currently limited by cost and concerns about cell durability. Improved understanding of their degradation modes and mechanisms combined with reduction–oxidation stable anodes via all-ceramic-anode cell technology are expected to lead to durability improvements, while economies of scale for production will mitigate cost of commercialization. This paper presents an Ishikawa analysis and a failure modes, mechanisms, effects, and criticality analysis (FMMECA) for all-ceramic anode based SOFCs. FMMECA takes into account the life cycle conditions, multiple failure mechanisms, and their potential effects on fuel-cell health and safety.