Identification of Novel Mechanisms in the Hypothalamus Linked to Adiposity.

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dc.contributor.advisorPorter, Tom Een_US
dc.contributor.authorByerly, Mardi Susannaen_US
dc.contributor.departmentNeuroscience and Cognitive Scienceen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2008-04-22T16:04:51Z
dc.date.available2008-04-22T16:04:51Z
dc.date.issued2007-12-05en_US
dc.description.abstractBody composition is a trait regulated by many different genes, giving rise to the severity of the phenotype in a continuous manner. We propose to investigate genetic interactions regulating obesity by focusing on genetic heretibility and genes that interact with Brain-Derived Neurotrophic Factor (BDNF) or thyroid hormone. We have utilized a novel model of obesity, genetically selected chicken lines, because differences in abdominal fat between the lines are based on genotype alone, independent of environmental influences. In order to identify novel gene networks that might give rise to the obese phenotype, hypothalamic gene expression was characterized using microarray technology. Hypothalamic neuronal cell cultures and in vivo manipulations were performed to verify that BDNF interacts with the hypothalamic-pituitary-thyroid axis, while simultaneously identifying novel genes that may interact together or independently of BDNF. A hypothetical model suggesting how BDNF and thyroid hormone reciprocally modulate genes in the hypothalamus already known to contribute to energy regulation was developed.en_US
dc.format.extent2595485 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/7690
dc.language.isoen_US
dc.subject.pqcontrolledBiology, Neuroscienceen_US
dc.subject.pqcontrolledBiology, Neuroscienceen_US
dc.subject.pquncontrolledObesityen_US
dc.subject.pquncontrolledhypothalamusen_US
dc.subject.pquncontrolledthyroid hormoneen_US
dc.subject.pquncontrolledglucocorticoidsen_US
dc.subject.pquncontrolledanabolic and catabolic gene expressionen_US
dc.subject.pquncontrolledbrain-derived neurotrophic factoren_US
dc.titleIdentification of Novel Mechanisms in the Hypothalamus Linked to Adiposity.en_US
dc.typeDissertationen_US

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