Influence of Vitamin D Receptor Gene Polymorphisms on Changes in Insulin Sensitivity with Aerobic Exercise Training

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dc.contributor.advisorHagberg, James Men_US
dc.contributor.authorHarne, Amanda Janelen_US
dc.contributor.departmentKinesiologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2005-02-02T07:03:02Z
dc.date.available2005-02-02T07:03:02Z
dc.date.issued2005-01-24en_US
dc.description.abstractThe purpose of the study was to examine the influence of the FokI and BsmI polymorphisms of the vitamin D receptor gene on changes in insulin sensitivity with aerobic exercise training in men and women at increased risk for type 2 diabetes mellitus (T2DM). Subjects were genotyped and underwent oral glucose tolerance tests before and after six months of training. Due to mis-genotyping of the BsmI polymorphism, results for that variant were not reported. There were no significant differences between FokI genotype groups in insulin sensitivity before or after training. However, among subjects who completed training, FF homozygotes had significantly higher baseline fasting glucose and insulin levels than f allele carriers. While the FokI polymorphism does not appear to mediate training-induced changes in indices of glucose and insulin metabolism, it may influence fasting glucose and insulin levels and the development of insulin resistance in individuals at increased risk for T2DM.en_US
dc.format.extent863931 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/2191
dc.language.isoen_US
dc.subject.pqcontrolledBiology, Geneticsen_US
dc.subject.pquncontrolledVDR geneen_US
dc.subject.pquncontrolledinsulin sensitivityen_US
dc.subject.pquncontrolledaerobic exercise trainingen_US
dc.titleInfluence of Vitamin D Receptor Gene Polymorphisms on Changes in Insulin Sensitivity with Aerobic Exercise Trainingen_US
dc.typeThesisen_US

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