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dc.contributor.advisorShackman, Alexander Jen_US
dc.contributor.authorKaplan, Claire Marjorieen_US
dc.date.accessioned2017-09-14T05:50:38Z
dc.date.available2017-09-14T05:50:38Z
dc.date.issued2017en_US
dc.identifierdoi:10.13016/M2F76674X
dc.identifier.urihttp://hdl.handle.net/1903/20044
dc.description.abstractThe anxiety-reducing properties of alcohol are thought to contribute to development of alcohol dependence, particularly among individuals with anxiety disorders. Remarkably little is known, however, about the neural circuitry underlying anxiolytic effects of alcohol in humans. In a sample of 72 healthy adults, we employed the novel MultiThreat Countdown (MTC) task to investigate the dose-dependent consequences of acute alcohol intoxication (BAL range: 0.061 - 0.145%) during anticipation of certain or uncertain threat, compared to placebo. Focal analyses of the central extended amygdala revealed significant activation during threat in the right, but not left, hemisphere for both the central nucleus [Ce] and bed nucleus of the stria terminalis [BST]. Increasing BALs were associated with decreasing activation in right BST and self-reported fear/anxiety levels during threat. This effect did not differ between certain and uncertain threat. These results build upon converging lines of evidence and suggest involvement of BST in alcohol-induced anxiolysis.en_US
dc.language.isoenen_US
dc.titleUnderstanding the anxiolytic effects of alcohol on the central extended amygdala in humansen_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentPsychologyen_US
dc.subject.pqcontrolledNeurosciencesen_US
dc.subject.pqcontrolledClinical psychologyen_US
dc.subject.pquncontrolledAlcoholen_US
dc.subject.pquncontrolledAmygdalaen_US
dc.subject.pquncontrolledAnxietyen_US
dc.subject.pquncontrolledFearen_US
dc.subject.pquncontrolledfMRIen_US
dc.subject.pquncontrolledThreaten_US


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